Sodium homeostasis and signalling: The core and the hub of astrocyte function

被引：10
|
作者：
Rose, Christine R. [1 ]
Verkhratsky, Alexej [2 ,3 ,4 ,5 ,6 ]
机构：
[1] Heinrich Heine Univ Dusseldorf, Inst Neurobiol, Fac Math & Nat Sci, D-40225 Dusseldorf, Germany
[2] Univ Manchester, Fac Biol Med & Hlth, Manchester M13 9PT, England
[3] Basque Fdn Sci, Achucarro Ctr Neurosci, IKERBASQUE, Bilbao 48011, Spain
[4] China Med Univ, Sch Forens Med, Dept Forens Analyt Toxicol, Shenyang, Peoples R China
[5] Chengdu Univ Tradit Chinese Med, Int Collaborat Ctr Big Sci Plan Purinerg Signaling, Chengdu, Peoples R China
[6] State Res Inst Ctr Innovat Med, Dept Stem Cell Biol, LT-01102 Vilnius, Lithuania
来源：
CELL CALCIUM | 2024年 / 117卷
关键词：
Astrocyte; Na plus signalling; SLC transporters; Na plus /K plus pump; pH regulation; Stroke; Hepatic encephalopathy; METHYL-D-ASPARTATE; MOUSE CORTICAL ASTROCYTES; GLIAL-CELLS; EXTRACELLULAR POTASSIUM; GLUTAMATE TRANSPORTERS; INTRACELLULAR SODIUM; GLYCINE TRANSPORTERS; K+ CHANNELS; RECEPTOR ACTIVATION; CL-COTRANSPORTER;
D O I：
10.1016/j.ceca.2023.102817
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Neuronal activity and neurochemical stimulation trigger spatio-temporal changes in the cytoplasmic concentration of Na+ ions in astrocytes. These changes constitute the substrate for Na+ signalling and are fundamental for astrocytic excitability. Astrocytic Na+ signals are generated by Na+ influx through neurotransmitter transporters, with primary contribution of glutamate transporters, and through cationic channels; whereas recovery from Na+ transients is mediated mainly by the plasmalemmal Na+/K+ ATPase. Astrocytic Na+ signals regulate the activity of plasmalemmal transporters critical for homeostatic function of astrocytes, thus providing real-time coordination between neuronal activity and astrocytic support.
引用
收藏
页数：15
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