Sodium homeostasis and signalling: The core and the hub of astrocyte function

被引：10

作者：

Rose, Christine R. ^{[1
]}

Verkhratsky, Alexej ^{[2
,3
,4
,5
,6
]}

机构：

[1] Heinrich Heine Univ Dusseldorf, Inst Neurobiol, Fac Math & Nat Sci, D-40225 Dusseldorf, Germany

[2] Univ Manchester, Fac Biol Med & Hlth, Manchester M13 9PT, England

[3] Basque Fdn Sci, Achucarro Ctr Neurosci, IKERBASQUE, Bilbao 48011, Spain

[4] China Med Univ, Sch Forens Med, Dept Forens Analyt Toxicol, Shenyang, Peoples R China

[5] Chengdu Univ Tradit Chinese Med, Int Collaborat Ctr Big Sci Plan Purinerg Signaling, Chengdu, Peoples R China

[6] State Res Inst Ctr Innovat Med, Dept Stem Cell Biol, LT-01102 Vilnius, Lithuania

来源：

CELL CALCIUM | 2024年 / 117卷

关键词：

Astrocyte; Na plus signalling; SLC transporters; Na plus /K plus pump; pH regulation; Stroke; Hepatic encephalopathy; METHYL-D-ASPARTATE; MOUSE CORTICAL ASTROCYTES; GLIAL-CELLS; EXTRACELLULAR POTASSIUM; GLUTAMATE TRANSPORTERS; INTRACELLULAR SODIUM; GLYCINE TRANSPORTERS; K+ CHANNELS; RECEPTOR ACTIVATION; CL-COTRANSPORTER;

D O I：

10.1016/j.ceca.2023.102817

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Neuronal activity and neurochemical stimulation trigger spatio-temporal changes in the cytoplasmic concentration of Na+ ions in astrocytes. These changes constitute the substrate for Na+ signalling and are fundamental for astrocytic excitability. Astrocytic Na+ signals are generated by Na+ influx through neurotransmitter transporters, with primary contribution of glutamate transporters, and through cationic channels; whereas recovery from Na+ transients is mediated mainly by the plasmalemmal Na+/K+ ATPase. Astrocytic Na+ signals regulate the activity of plasmalemmal transporters critical for homeostatic function of astrocytes, thus providing real-time coordination between neuronal activity and astrocytic support.

引用

页数：15

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