Brucellosis is one of the most common zoonotic diseases caused by Brucella bacteria and is characterized with nonspecific findings such as corrugated fever, sweating, myalgia, joint pain, loss of appetite, nausea, vomiting, fatigue, weakness, weight loss, headache, and dizziness. The involvement of the nervous system is rare. We aimed to present two cases of paraplegia due to radiculitis and loss of upper extremity strength due to cervical abscess after infection caused by Brucella. In the etiology of fever of unknown origin in areas where Brucella is endemic, brucellosis is a disease that must be considered in the differential diagnosis. If early diagnosis and appropriate treatment are not given, it can leave serious neurological sequelae. Recognition and treatment by physicians in endemic areas is of critical importance.