Neurostimulation as a Putative Method for the Treatment of Drug-resistant Epilepsy in Patient and Animal Models of Epilepsy

被引：1

作者：

Bakhtiarzadeh, Fatemeh ^{[1
]}

Zare, Meysam ^{[1
]}

Ghasemi, Zahra ^{[2
]}

Dehghan, Samaneh ^{[3
,4
]}

Sadeghin, Azam ^{[1
]}

Joghataei, Mohammad Taghi ^{[5
,6
]}

Ahmadirad, Nooshin ^{[6
]}

机构：

[1] Tarbiat Modares Univ, Fac Med Sci, Dept Physiol, Tehran, Iran

[2] Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada

[3] Iran Univ Med Sci, Stem cell & Regenerat Med Res Ctr, Tehran, Iran

[4] Iran Univ Med Sci, Rasool Akram Hosp, Five Senses Hlth Inst, Eye Res Ctr, Tehran, Iran

[5] Iran Univ Med Sci, Sch Med, Dept Anat & Neurosci, Tehran, Iran

[6] Iran Univ Med Sci, Cellular & Mol Res Ctr, Tehran, Iran

来源：

BASIC AND CLINICAL NEUROSCIENCE | 2023年 / 14卷 / 01期

关键词：

Drug-resistant epilepsy Vagus; nerve stimulation Trigeminal; nerve stimulation Responsive; stimulation system Deep brain; stimulation; VAGUS NERVE-STIMULATION; FREQUENCY ELECTRICAL-STIMULATION; DEEP BRAIN-STIMULATION; MEDICALLY REFRACTORY EPILEPSY; LONG-TERM POTENTIATION; RESPONSIVE NEUROSTIMULATION; EPILEPTIFORM ACTIVITY; ANTERIOR NUCLEUS; THALAMIC NUCLEUS; INTRACTABLE EPILEPSY;

D O I：

10.32598/bcn.2022.2360.4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A patient with epilepsy was shown to have neurobiological, psychological, cognitive, and social issues as a result of recurring seizures, which is regarded as a chronic brain disease. However, despite numerous drug treatments, approximately, 30%-40% of all patients are resistant to antiepileptic drugs. Therefore, newer therapeutic modalities are introduced into clinical practice which involve neurostimulation and direct stimulation of the brain. Hence, we review published literature on vagus nerve stimulation, trigeminal nerve stimulation, applying responsive stimulation systems, and deep brain stimulation (DBS) in animals and epileptic patient with an emphasis on drug-resistant epilepsy.

引用

页码：1 / 18

页数：18

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