Role of vascular endothelial growth factor in radiotherapy resistance to esophageal squamous cell carcinoma

被引：6
|
作者：
Li, Xin [1 ]
Su, Xinyu [2 ]
Yan, Chen [1 ]
Ma, Yuanyuan [1 ]
Li, Heng [1 ]
Xia, Jianhong [1 ]
Li, Hongliang [1 ]
Jiang, Qian [1 ]
Zhou, Liqing [1 ]
Zou, Zhengyun [2 ,3 ,4 ]
机构：
[1] Xuzhou Med Univ, Dept Radiat Oncol, Huaian Hosp, Huaian City, Jiangsu, Peoples R China
[2] Nanjing Univ, Dept Radiat Oncol, Ctr Comprehens Canc,Med Sch, Nanjing Drum Tower Hosp,Affiliated Drum Tower Hos, Nanjing, Peoples R China
[3] Nanjing Med Univ, Dept Radiat Oncol, Ctr Comprehens Canc, Nanjing Drum Tower Hosp,Clin Coll, Nanjing, Peoples R China
[4] Nanjing Univ Chinese Med, Dept Radiat Oncol, Ctr Comprehens Canc, Nanjing Drum Tower Hosp,Clin Coll, Nanjing, Peoples R China
来源：
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2023年 / 149卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Esophageal carcinoma; Vascular endothelial growth factor; Radiotherapy; Curative effect; Anti-angiogenesis; ANTIANGIOGENIC THERAPY; BEVACIZUMAB; INHIBITION; RADIATION; RADIOSENSITIVITY; ANGIOGENESIS; MARKERS; VEGF;
D O I：
10.1007/s00432-022-04122-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Vascular endothelial growth factor (VEGF) is related to the radiation resistance of tumors, resulting in the failure of tumor radiotherapy. The purpose of this study was to discuss the role of VEGF in radiotherapy resistance of esophageal squamous cell carcinoma (ESCC). We used the VEGF kit by ELISA to detect the serum VEGF level of ESCC patients who only received radiotherapy. The expression of VEGF in ESCC cells after siRNA treatment was verified by Western blot. The sensitivity of ESCC cells to radiation after knocking down VEGF was analyzed by Clonogenic assay and Cell counting kit (CCK-8). The results showed that the level of serum VEGF in patients with ESCC before and after radiotherapy was related to the clinical response, and it was confirmed that knocking down the expression of VEGF in ESCC cells improved the sensitivity to radiation.
引用
收藏
页码：2543 / 2550
页数：8
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