DNA nanostructures as biomolecular scaffolds for antigen display

被引：0
|
作者：
Chen, Kun [1 ,2 ]
Jiang, Ming [1 ]
Liu, Jin [1 ,3 ]
Huang, Deli [4 ]
Yang, Yuhe R. R. [1 ,5 ]
机构：
[1] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Nanosyst & Hierarch Fabricat, Beijing 100190, Peoples R China
[2] Beijing Univ Chem Technol, Mat Sci & Engn, Beijing, Peoples R China
[3] Air Force Med Univ, Tangdu Hosp, Xian, Peoples R China
[4] Zhejiang Univ, Life Sci Inst, Hangzhou, Peoples R China
[5] Univ Chinese Acad Sci, Beijing, Peoples R China
来源：
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY | 2024年 / 16卷 / 01期
基金：
中国国家自然科学基金;
关键词：
B cell activation; DNA nanostructure; DNA-protein conjugation; nanoparticle-based vaccines; protein NPs; SINGLE-STRANDED-DNA; CRYO-EM STRUCTURE; ORIGAMI NANOSTRUCTURES; ANTIBODY-RESPONSES; CLICK CHEMISTRY; DENDRITIC CELLS; FUSION PROTEINS; VACCINE; NANOPARTICLES; STREPTAVIDIN;
D O I：
10.1002/wnan.1921
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Nanoparticle-based vaccines offer a multivalent approach for antigen display, efficiently activating T and B cells in the lymph nodes. Among various nanoparticle design strategies, DNA nanotechnology offers an innovative alternative platform, featuring high modularity, spatial addressing, nanoscale regulation, high functional group density, and lower self-antigenicity. This review delves into the potential of DNA nanostructures as biomolecular scaffolds for antigen display, addressing: (1) immunological mechanisms behind nanovaccines and commonly used nanoparticles in their design, (2) techniques for characterizing protein NP-antigen complexes, (3) advancements in DNA nanotechnology and DNA-protein assembly approach, (4) strategies for precise antigen presentation on DNA scaffolds, and (5) current applications and future possibilities of DNA scaffolds in antigen display. This analysis aims to highlight the transformative potential of DNA nanoscaffolds in immunology and vaccinology.This article is categorized under:Biology-Inspired Nanomaterials > Nucleic Acid-Based StructuresBiology-Inspired Nanomaterials > Protein and Virus-Based Structures
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页数：24
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