Difunctionalization of alkenes proceeding with radical 1,2-alkynyl migration in batch and continuous-flow modes

被引：1
|
作者：
Mao, Ziren [1 ]
Zhou, Yiliang [1 ]
Zhang, Jingming [1 ]
Liu, Chengkou [1 ]
Wang, Chang-Sheng [1 ]
Yang, Xiaobing [2 ]
Qin, Hong [1 ]
Fang, Zheng [1 ]
Guo, Kai [1 ,3 ]
机构：
[1] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, Nanjing 211816, Peoples R China
[2] Jiangsu Ind Technol Res Inst, China Biol & Med Dept, Nanjing 210031, Peoples R China
[3] Nanjing Tech Univ, State Key Lab Mat Oriented Chem Engn, Nanjing 211816, Peoples R China
来源：
NEW JOURNAL OF CHEMISTRY | 2024年 / 48卷 / 04期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
UNACTIVATED ALKENES; METAL-FREE;
D O I：
10.1039/d3nj05081e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient strategy to construct alpha-alkynyl ketones through electrochemical difunctionalization of alkenes was developed. This method is oxidant-free, metal-free, high-efficiency and eco-friendly, and offers rapid constructions of 1,2-alkynyl migration products through the radical process of 3-exo-dig cyclization. Moreover, the reaction could undergo a successful transformation under continuous-flow conditions. A straightforward method for electrochemical difunctionalization of alkenes to construct the corresponding alpha-alkynyl ketone product under catalyst- and oxidant-free conditions in batch and continuous-flow modes was developed.
引用
收藏
页码：1735 / 1740
页数：6
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