Genomic Regions and Candidate Genes Associated with Milk Production Traits in Holstein and Its Crossbred Cattle: A Review

被引:11
|
作者
Bekele, R. [1 ,2 ]
Taye, M. [1 ]
Abebe, G. [1 ]
Meseret, S. [3 ]
机构
[1] Hawassa Univ, Coll Agr, Sch Anim & Range Sci, POB 5, Hawassa, Ethiopia
[2] Debre Berhan Univ, Coll Agr & Nat Resource Sci, Dept Anim Sci, POB 445, Debre Berhan, Ethiopia
[3] Int Livestock Res Inst ILRI, Livestock Genet, Addis Ababa, Ethiopia
关键词
SOMATIC-CELL SCORE;
D O I
10.1155/2023/8497453
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Genome-wide association studies (GWAS) are a powerful tool for identifying genomic regions and causative genes associated with economically important traits in dairy cattle, particularly complex traits, such as milk production. This is possible due to advances in next-generation sequencing technology. This review summarized information on identified candidate genes and genomic regions associated with milk production traits in Holstein and its crossbreds from various regions of the world. Milk production traits are important in dairy cattle breeding programs because of their direct economic impact on the industry and their close relationship with nutritional requirements. GWAS has been used in a large number of studies to identify genomic regions and candidate genes associated with milk production traits in dairy cattle. Many genomic regions and candidate genes have already been identified in Holstein and its crossbreds. Genes and single nucleotide polymorphisms (SNPs) that significantly affect milk yield (MY) were found in all autosomal chromosomes except chromosomes 27 and 29. Half of the reported SNPs associated with fat yield and fat percentage were found on chromosome 14. However, a large number of significant SNPs for protein yield (PY) and protein percentage were found on chromosomes 1, 5, and 20. Approximately 155 SNPs with significant influence on multiple milk production traits have been identified. Several promising candidate genes, including diacylglycerol O-acyltransferase 1, plectin, Rho GTPase activating protein 39, protein phosphatase 1 regulatory subunit 16A, and sphingomyelin phosphodiesterase 5 were found to have pleiotropic effects on all five milk production traits. Thus, to improve milk production traits it is of practical relevance to focus on significant SNPs and pleiotropic genes frequently found to affect multiple milk production traits.
引用
收藏
页数:18
相关论文
共 50 条
  • [21] Genomic insights into selection signatures and candidate genes for milk production traits in buffalo population
    Deng, T. X.
    Ma, X. Y.
    Duan, A. Q.
    Lu, X. R.
    Abdel-Shafy, H.
    ANIMAL, 2025, 19 (04)
  • [22] Indirect genomic predictions for milk yield in crossbred Holstein-Jersey dairy cattle
    Steyn, Y.
    Gonzalez-Pena, D.
    Rubio, Y. L. Bernal
    Vukasinovic, N.
    DeNise, S. K.
    Lourenco, D. A. L.
    Misztal, I
    JOURNAL OF DAIRY SCIENCE, 2021, 104 (05) : 5728 - 5737
  • [23] Frequencies of candidate genes and associations with carcass and meat traits in Nellore and crossbred cattle
    Domingos Dias, Victor Augusto
    Curi, Rogerio Abdallah
    Pereira, Guilherme Luis
    Malheiros, Jessica Moraes
    Espigolan, Rafael
    de Albuquerque, Lucia Galvao
    Loyola Chardulo, Luis Artur
    de Oliveira, Henrique Nunes
    PESQUISA AGROPECUARIA BRASILEIRA, 2016, 51 (02) : 169 - 176
  • [24] Candidate genes for production traits in Nelore beef cattle
    Tizioto, P. C.
    Meirelles, S. L.
    Tulio, R. R.
    Rosa, A. N.
    Alencar, M. M.
    Medeiros, S. R.
    Siqueira, F.
    Feijo, G. L. D.
    Silva, L. O. C.
    Torres Junior, R. A. A.
    Regitano, L. C. A.
    GENETICS AND MOLECULAR RESEARCH, 2012, 11 (04) : 4138 - 4144
  • [25] A COMPARISON OF MILK-PRODUCTION TRAITS IN FRIESIANXWHITE FULANI CROSSBRED CATTLE
    BUVANENDRAN, V
    OLAYIWOLE, MB
    PIOTROWSKA, KI
    OYEJOLA, BA
    ANIMAL PRODUCTION, 1981, 32 (APR): : 165 - 170
  • [26] Genetic analysis of milk production efficiency traits in Jersey crossbred cattle
    Ratwan, Poonam
    Mandal, Ajoy
    Kumar, Manoj
    Chakravarty, A. K.
    INDIAN JOURNAL OF ANIMAL RESEARCH, 2017, 51 (04) : 644 - 647
  • [27] Genotype Environment interactions for milk production traits in Holstein and crossbred Holstein-Zebu cattle populations estimated by a character state multibreed model
    Menendez-Buxadera, Alberto
    Palacios-Espinosa, Alejandro
    Luis Espinosa-Villavicencio, Jose
    Guerra-Iglesias, Danilo
    LIVESTOCK SCIENCE, 2016, 191 : 108 - 116
  • [28] Whole Genome Scan Uncovers Candidate Genes Related to Milk Production Traits in Barka Cattle
    Ayalew, Wondossen
    Wu, Xiaoyun
    Tarekegn, Getinet Mekuriaw
    Sisay Tessema, Tesfaye
    Naboulsi, Rakan
    Van Damme, Renaud
    Bongcam-Rudloff, Erik
    Edea, Zewdu
    Chu, Min
    Enquahone, Solomon
    Liang, Chunnian
    Yan, Ping
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (11)
  • [29] On the genomic regions associated with milk lactose in Fleckvieh cattle
    Costa, Angela
    Schwarzenbacher, Hermann
    Meszaros, Gabor
    Fuerst-Waltl, Birgit
    Fuerst, Christian
    Soelkner, Johann
    Penasa, Mauro
    JOURNAL OF DAIRY SCIENCE, 2019, 102 (11) : 10088 - 10099
  • [30] A Comparison between Crossbred (Holstein x Local Cattle) and Bangladeshi Local Cattle for Body and Milk Quality Traits
    Saha, Sudeb
    Hasan, Md. Nazmul
    Uddin, Md. Nazim
    Rahman, B. M. Masiur
    Khan, Mohammad Mehedi Hasan
    Ahmed, Syed Sayeem Uddin
    Kitazawa, Haruki
    DAIRY, 2024, 5 (01) : 153 - 160