Anterior segment optical coherence tomography in iris and ciliary body tumors: a systematic review

IntroductionIris/ciliary body tumors can broadly be classified as benign or malignant, cystic or solid, and melanocytic or non-melanocytic. This study aims to provide a systematic review of anterior segment optical coherence tomography (AS-OCT) findings in iris and ciliary body tumors.MethodsWe conducted a search of published articles related to the use of AS-OCT in iris/ciliary body tumors as of December 2022. Databases that were searched included PubMed, Scopus, and Web of Science. The following search terms in various combinations were used: 'anterior segment optical coherence tomography,' 'ciliary body melanoma,' 'ciliary body nevus,' 'ciliary body tumor,' 'iris cyst,' 'iris melanoma,' 'iris nevus,' 'iris tumor,' and 'metastasis.'ResultsA total of 41 studies (10 original articles and 31 case reports) met the inclusion criteria. AS-OCT data pertaining to 545 iris/ciliary body lesions could be retrieved.ConclusionAS-OCT has proved to be useful as a noninvasive tool for the diagnosis of solid tumors involving the iris/angle with no marked ciliary body involvement, iris pigment epithelial, and iris stromal cysts. To the best of our knowledge, this is the first systematic review in the literature evaluating the utility of AS-OCT in iris/ciliary body tumors.