p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer

被引：0

作者：

Fischer, Martin ^{[1
]}

机构：

[1] Fritz Lipmann Inst FLI, Leibniz Inst Aging, Computat Biol Grp, Beutenbergstr 11, D-07745 Jena, Germany

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2023年 / 19卷 / 15期

关键词：

tumor suppressor p53; transcription factor MYC; SQLE; cholesterol synthesis; Terbinafine; colorectal cancer;

D O I：

10.7150/ijbs.89237

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transcription factors p53 and MYC are often considered non-druggable targets, but their dysregulation can generate new dependencies and treatment opportunities in cancer cells. The p53 and MYC-regulated squalene epoxidase (SQLE) has been identified as a potential Achilles heel in colorectal cancer. This is of great interest because the FDA-approved anti-fungal SQLE inhibitor Terbinafine could be repurposed to treat colorectal cancer patients.

引用

页码：4831 / 4832

页数：2

共 50 条

[21] A squalene epoxidase-cholesterolaxis drives colorectal cancer progression and metastatic dissemination
Jun, Soo Young
Brown, Andrew J.
Yoon, Ji-Yong
Lee, Jeong-Ju
Chua, Ngee Kiat
Yang, Jin O. K.
Min, Ju-Sik
Jang, Insu
Jeon, Su-Jin
Choi, Min-Hyuk
Choi, Tae-Ik
Kim, Cheol-Hee
Kim, Nam-Soon
CANCER RESEARCH, 2019, 79 (13)
[22] Overexpression of p53 mRNA in colorectal cancer and its relationship to p53 gene mutation
ElMahdani, N
Vaillant, JC
Guiguet, M
Prevot, S
Bertrand, V
Bernard, C
Parc, R
Bereziat, G
Hermelin, B
BRITISH JOURNAL OF CANCER, 1997, 75 (04) : 528 - 536
[23] Overexpression of p53 mRNA in colorectal cancer and its relationship to p53 gene mutation
N el-Mahdani
J-C Vaillant
M Guiguet
S Prévot
V Bertrand
C Bernard
R Parc
G Béréziat
B Hermelin
British Journal of Cancer, 1997, 75 : 528 - 536
[24] A polymorphic MYC response element in KBTBD11 influences colorectal cancer risk, especially in interaction with an MYC-regulated SNP rs6983267
Gong, J.
Tian, J.
Lou, J.
Wang, X.
Ke, J.
Li, J.
Yang, Y.
Gong, Y.
Zhu, Y.
Zou, D.
Peng, X.
Yang, N.
Mei, S.
Zhong, R.
Chang, J.
Miao, X.
ANNALS OF ONCOLOGY, 2018, 29 (03) : 632 - 639
[25] Reduction of Squalene Epoxidase by Cholesterol Accumulation Accelerates Colorectal Cancer Progression and Metastasis
Jun, Soo Young
Brown, Andrew J.
Chua, Ngee Kiat
Yoon, Ji-Yong
Lee, Jeong-Ju
Yang, Jin Ok
Jang, InSu
Jeon, Su-Jin
Choi, Tae-Ik
Kim, Cheol-Hee
Kim, Nam-Soon
GASTROENTEROLOGY, 2021, 160 (04) : 1194 - +
[26] p53 autoantibodies in sera of patients with a colorectal cancer and their association to p53 protein concentration and p53 immunohistochemistry in tumor tissue
R. Broll
M. Duchrow
E. Oevermann
C. Wellm
O. Schwandner
H. Schimmelpenning
U.J. Roblick
H.P. Bruch
U. Windhövel
International Journal of Colorectal Disease, 2001, 16 : 22 - 27
[27] p53 autoantibodies in sera of patients with a colorectal cancer and their association to p53 protein concentration and p53 immunohistochemistry in tumor tissue
Broll, R
Duchrow, M
Oevermann, E
Wellm, C
Schwandner, O
Schimmelpenning, H
Roblick, UJ
Bruch, HP
Windhövel, U
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2001, 16 (01) : 22 - 27
[28] Cytoplasmic retention of p53 in colorectal cancer cells
Milicevic, ZT
Petrovic, MV
Mihailovic, MV
Bogojevic, DB
FEBS JOURNAL, 2005, 272 : 127 - 128
[29] SCREENING FOR P53 MUTATIONS IN COLORECTAL-CANCER
TRIANTAFILLOU, N
MACERA, MJ
SMITH, LJ
NEWMAN, L
EARLE, D
GROSMAN, I
VERMA, RS
AMERICAN JOURNAL OF HUMAN GENETICS, 1995, 57 (04) : 1764 - 1764
[30] Socioeconomic status, p53 abnormalities, and colorectal cancer
Vogtmann, Emily
Shanmugam, Chandrakumar
Katkoori, Venkat R.
Waterbor, John
Manne, Upender
JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2013, 4 (01) : 40 - 44

← 1 2 3 4 5 →