p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer

被引：0
|
作者：
Fischer, Martin [1 ]
机构：
[1] Fritz Lipmann Inst FLI, Leibniz Inst Aging, Computat Biol Grp, Beutenbergstr 11, D-07745 Jena, Germany
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2023年 / 19卷 / 15期
关键词：
tumor suppressor p53; transcription factor MYC; SQLE; cholesterol synthesis; Terbinafine; colorectal cancer;
D O I：
10.7150/ijbs.89237
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The transcription factors p53 and MYC are often considered non-druggable targets, but their dysregulation can generate new dependencies and treatment opportunities in cancer cells. The p53 and MYC-regulated squalene epoxidase (SQLE) has been identified as a potential Achilles heel in colorectal cancer. This is of great interest because the FDA-approved anti-fungal SQLE inhibitor Terbinafine could be repurposed to treat colorectal cancer patients.
引用
收藏
页码：4831 / 4832
页数：2
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