Polyketides with anti-inflammatory activity isolated from Rhodiola tibetica endophytic fungus Penicillium sp. HJT-A-10

被引：3
|
作者：
Lu, Xuan [1 ]
Qi, Jun-kai [1 ]
Tang, Xiao-yuan [1 ]
Wang, Xu-de [2 ]
Ye, Chong-tao [2 ]
Bai, Jing [3 ]
Tang, Chuan [1 ]
Xi, Yu-fei [1 ]
Wu, Bin [4 ]
Wan, Xue [4 ]
Feng, Bao-min [1 ]
机构：
[1] Dalian Univ, Coll Life & Hlth, Dalian 116622, Peoples R China
[2] Dalian Univ, Med Coll, Dalian 116622, Peoples R China
[3] Suzhou Univ Sci & Technol, Sch Chem & Life Sci, Suzhou 215009, Peoples R China
[4] China Certificat & Inspection Grp Liaoning Co Ltd, Dalian 116622, Peoples R China
来源：
FITOTERAPIA | 2023年 / 164卷
关键词：
Penicillium sp; Polyketides; Tanzawaic acid; Anti-inflammatory activity; MARINE-DERIVED FUNGUS; DIELS-ALDER REACTION; BIOSYNTHESIS; ACIDS;
D O I：
10.1016/j.fitote.2022.105361
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Seven undescribed polyketide compounds (1-4, 9-11) and six known polyketide compounds (5-8,12, 13) were isolated from Rhodiola tibetica endophytic Penicillium sp. HJT-A-10. The structural of seven undescribed poly-ketides metabolites were established on the basis of spectroscopic methods. The results of anti-inflammatory activity showed that compounds 1-8,10-13 had significant inhibitory effects on LPS-induced NO production in RAW 264.7 cells.
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页数：9
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