Derivation of Benzothiadiazine-1,1-dioxide Scaffolds via Transition Metal-Catalyzed C-H Activation/Annulation

Comprehensive SummaryBenzothiadiazine-1,1-dioxide scaffold is bioactive framework with wild utility and applications. Synthesis of benzothiadiazine-fused isoquinoline derivatives and spiro benzothiadiazine derivatives through transition metal-catalyzed C-H activation/annulation was reported. 3-Phenyl-2H-benzothiadiazine-1,1-dioxide was used as the reaction substrate, and vinylene carbonate and 4-diazopyrazolone were used as the coupling reagents, respectively. This strategy provides straightforward access to complex N-heterocycles in a highly efficient and simple manner.