GS-441524 Parent Nucleoside to Remdesivir Can Effectively Inhibits Sars-Cov-2 Omicron Infections in Human Lung Organoids

被引：0
|
作者：
Liang, J. [1 ]
Li, Y. [2 ]
Khateeb, J. [3 ]
Khang, J. [4 ]
Slutsky, A. [5 ]
Mubareka, S. [6 ]
Zhang, H. [7 ]
机构：
[1] Univ Toronto, Physiol, Toronto, ON, Canada
[2] Guangzhou Med Univ, Guangzhou Inst Resp Dis, State Key Lab Resp Dis, Affiliated Hosp 1, Guangzhou, Peoples R China
[3] Rambam Hlth Care Campus, Internal Med, Haifa, Israel
[4] St Michaels Hosp, Keenan Res Ctr Biomed Sci, Anesthesia, Toronto, ON, Canada
[5] St Michaels Hosp, Interdepartmental Div Crit Care Medici, Toronto, ON, Canada
[6] Sunnybrook Hlth Sci Ctr, Lab Med & Pathobiol, Toronto, ON, Canada
[7] St Michaels Hosp, Anesthesia & Pain Med, Toronto, ON, Canada
来源：
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2023年 / 207卷
基金：
加拿大健康研究院;
关键词：
D O I：
暂无
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
A3983
引用
收藏
页数：2
相关论文
共 50 条
  • [21] Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys
    Mackman, Richard L.
    Kalla, Rao V.
    Babusis, Darius
    Pitts, Jared
    Barrett, Kimberly T.
    Chun, Kwon
    Du Pont, Venice
    Rodriguez, Lauren
    Moshiri, Jasmine
    Xu, Yili
    Lee, Michael
    Lee, Gary
    Bleier, Blake
    Nguyen, Anh-Quan
    O'Keefe, B. Michael
    Ambrosi, Andrea
    Cook, Meredith
    Yu, Joy
    Dempah, Kassibla Elodie
    Bunyan, Elaine
    Riola, Nicholas C.
    Lu, Xianghan
    Liu, Renmeng
    Davie, Ashley
    Hsiang, Tien-Ying
    Dearing, Justin
    Vermillion, Meghan
    Gale Jr, Michael
    Niedziela-Majka, Anita
    Feng, Joy Y.
    Hedskog, Charlotte
    Bilello, John P.
    Subramanian, Raju
    Cihlar, Tomas
    JOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (17) : 11701 - 11717
  • [22] Establishment of human distal lung organoids for SARS-CoV-2 infection
    Ting Wang
    Ning Zhang
    Shipan Fan
    Lianzheng Zhao
    Wanlu Song
    Yuhuan Gong
    Quan Shen
    Cheng Zhang
    Peng Ren
    Chutong Lin
    Wei Fu
    George F. Gao
    Shaohua Ma
    Yuhai Bi
    Ye-Guang Chen
    Cell Discovery, 7
  • [23] Establishment of human distal lung organoids for SARS-CoV-2 infection
    Wang, Ting
    Zhang, Ning
    Fan, Shipan
    Zhao, Lianzheng
    Song, Wanlu
    Gong, Yuhuan
    Shen, Quan
    Zhang, Cheng
    Ren, Peng
    Lin, Chutong
    Fu, Wei
    Gao, George F.
    Ma, Shaohua
    Bi, Yuhai
    Chen, Ye-Guang
    CELL DISCOVERY, 2021, 7 (01)
  • [24] Artificial Neural Network-Based Study Predicts GS-441524 as a Potential Inhibitor of SARS-CoV-2 Activator Protein Furin: a Polypharmacology Approach
    M. Dhanalakshmi
    Kajari Das
    Medha Pandya
    Sejal Shah
    Ayushman Gadnayak
    Sushma Dave
    Jayashankar Das
    Applied Biochemistry and Biotechnology, 2022, 194 : 4511 - 4529
  • [25] A hnRNPA2B1 agonist effectively inhibits HBV and SARS-CoV-2 omicron in vivo
    Daming Zuo
    Yu Chen
    Jianpiao Cai
    HaoYang Yuan
    JunQi Wu
    Yue Yin
    JingWen Xie
    JingMin Lin
    Jia Luo
    Yang Feng
    LongJiao Ge
    Jia Zhou
    Ronald J Quinn
    SanJun Zhao
    Xing Tong
    DongYan Jin
    Shuofeng Yuan
    ShaoXing Dai
    Min Xu
    Protein & Cell, 2023, 14 (01) : 37 - 50
  • [26] A hnRNPA2B1 agonist effectively inhibits HBV and SARS-CoV-2 omicron in vivo
    Zuo, Daming
    Chen, Yu
    Cai, Jian-piao
    Yuan, Hao-Yang
    Wu, Jun-Qi
    Yin, Yue
    Xie, Jing-Wen
    Lin, Jing-Min
    Luo, Jia
    Feng, Yang
    Ge, Long-Jiao
    Zhou, Jia
    Quinn, Ronald J.
    Zhao, San-Jun
    Tong, Xing
    Jin, Dong-Yan
    Yuan, Shuofeng
    Dai, Shao-Xing
    Xu, Min
    PROTEIN & CELL, 2023, 14 (01) : 37 - 50
  • [27] Enhanced replication of SARS-CoV-2 Omicron BA.2 in human forebrain and midbrain organoids
    Yuxin Hou
    Chang Li
    Chaemin Yoon
    On Wah Leung
    Sikun You
    Xiaoming Cui
    Jasper Fuk-Woo Chan
    Duanqing Pei
    Hoi Hung Cheung
    Hin Chu
    Signal Transduction and Targeted Therapy, 7
  • [28] Enhanced replication of SARS-CoV-2 Omicron BA.2 in human forebrain and midbrain organoids
    Hou, Yuxin
    Li, Chang
    Yoon, Chaemin
    Leung, On Wah
    You, Sikun
    Cui, Xiaoming
    Chan, Jasper Fuk-Woo
    Pei, Duanqing
    Cheung, Hoi Hung
    Chu, Hin
    SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2022, 7 (01)
  • [29] Progenitor identification and SARS-CoV-2 infection in human distal lung organoids
    Ameen A. Salahudeen
    Shannon S. Choi
    Arjun Rustagi
    Junjie Zhu
    Vincent van Unen
    Sean M. de la O
    Ryan A. Flynn
    Mar Margalef-Català
    António J. M. Santos
    Jihang Ju
    Arpit Batish
    Tatsuya Usui
    Grace X. Y. Zheng
    Caitlin E. Edwards
    Lisa E. Wagar
    Vincent Luca
    Benedict Anchang
    Monica Nagendran
    Khanh Nguyen
    Daniel J. Hart
    Jessica M. Terry
    Phillip Belgrader
    Solongo B. Ziraldo
    Tarjei S. Mikkelsen
    Pehr B. Harbury
    Jeffrey S. Glenn
    K. Christopher Garcia
    Mark M. Davis
    Ralph S. Baric
    Chiara Sabatti
    Manuel R. Amieva
    Catherine A. Blish
    Tushar J. Desai
    Calvin J. Kuo
    Nature, 2020, 588 : 670 - 675
  • [30] Progenitor identification and SARS-CoV-2 infection in human distal lung organoids
    Salahudeen, Ameen A.
    Choi, Shannon S.
    Rustagi, Arjun
    Zhu, Junjie
    van Unen, Vincent
    De la O, Sean M.
    Flynn, Ryan A.
    Margalef-Catala, Mar
    Santos, Antonio J. M.
    Ju, Jihang
    Batish, Arpit
    Usui, Tatsuya
    Zheng, Grace X. Y.
    Edwards, Caitlin E.
    Wagar, Lisa E.
    Luca, Vincent
    Anchang, Benedict
    Nagendran, Monica
    Nguyen, Khanh
    Hart, Daniel J.
    Terry, Jessica M.
    Belgrader, Phillip
    Ziraldo, Solongo B.
    Mikkelsen, Tarjei S.
    Harbury, Pehr B.
    Glenn, Jeffrey S.
    Garcia, K. Christopher
    Davis, Mark M.
    Baric, Ralph S.
    Sabatti, Chiara
    Amieva, Manuel R.
    Blish, Catherine A.
    Desai, Tushar J.
    Kuo, Calvin J.
    NATURE, 2020, 588 (7839) : 670 - +
12345