Neuropsychiatric outcomes and caregiver distress in primary progressive aphasia

被引：1
|
作者：
Seckin, Mustafa [1 ,2 ]
Yildirim, Elif [3 ]
Demir, Ilayda [4 ,5 ]
Orhun, Omer [2 ]
Bulbul, Ezgi [2 ]
Velioglu, H. Aziz [6 ]
Oktem, Oget [7 ]
Yesilot, Nilufer [8 ]
Coban, Oguzhan [8 ]
Gurvit, Hakan [7 ]
机构：
[1] Acibadem Mehmet Ali Aydinlar Univ, Dept Neurol, Sch Med, Istanbul, Turkey
[2] Acibadem Mehmet Ali Aydinlar Univ, Alzheimers Dis & Cognit Neurol Res Lab, Sch Med, Istanbul, Turkey
[3] Isik Univ, Fac Econ Adm & Social Sci, Dept Psychol, Istanbul, Turkey
[4] Istanbul Univ, Dept Neurosci, Aziz Sancar Inst Expt Med, Istanbul, Turkey
[5] Istanbul Univ, Hulusi Behcet Life Sci Ctr, Neuroimaging Lab, Istanbul, Turkey
[6] Istanbul Medipol Univ, Regenerat & Restorat Med Res Ctr REMER, Hlth Sci & Technol Res Inst SABITA, Funct Imaging & Cognit Affect Neurosci Lab fINCAN, Istanbul, Turkey
[7] Istanbul Univ, Dept Neurol, Behav Neurol & Movement Disorders Unit, Fac Med, Istanbul, Turkey
[8] Istanbul Univ, Dept Neurol, Edip Aktin Stroke Unit, Fac Med, Istanbul, Turkey
来源：
PSYCHOGERIATRICS | 2023年 / 23卷 / 01期
关键词：
behaviour; caregiver burden; Neuropsychiatric Inventory; primary progressive aphasia; stroke aphasia; ALZHEIMERS-DISEASE; BEHAVIORAL VARIANT; BURDEN; SYMPTOMS; INVENTORY; DISTURBANCES; RELIABILITY; VALIDITY; APRAXIA; ANATOMY;
D O I：
10.1111/psyg.12902
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Background In this study, we aimed to outline the neuropsychiatric consequences of primary progressive aphasia (PPA) and to understand how neuropsychiatric symptomatology affects distress in caregivers. Methods The Neuropsychiatric Inventory (NPI) including the distress index (NPI-Distress) was used. Additional information about the caregiver burden was obtained using Zarit Burden Interview (ZBI). NPI, NPI-Distress, and ZBI data from 17 patients with a clinical diagnosis of PPA were compared with 10 stroke aphasia patients. Neuropsychiatric symptomatology was investigated based on three clusters; Mood, Frontal/Comportmental, and Psychotic/Disruptive. Additionally, the Activities of Daily Living Questionnaire (ADLQ) was used to outline the functional impairment. Twelve healthy controls were included to compare the neurocognitive test scores with PPA and stroke aphasia groups. Results A greater number of neuropsychiatric symptoms were observed in the PPA group compared to the stroke aphasia group. The number of symptoms in Mood, and Frontal/Comportmental clusters were greater than the number of symptoms in Psychotic/Disruptive clusters in the PPA group, whereas no significant relationship between the number of symptoms and symptom clusters was found in the stroke aphasia group. In the PPA group, a strong correlation was found between the NPI-Frequency x Severity scores and the NPI-Distress scores. Moreover, the NPI-Distress scores in the PPA group strongly correlated with the ZBI scores. Scores for anxiety, irritability/lability, and apathy had a stronger correlation with the NPI-Distress scores compared to the other NPI symptoms. The Communication subscale was the most impaired domain in the PPA group. Travel, and Employment and Recreation subscales showed greater functional impairment in the stroke aphasia group compared to the PPA group. Conclusions Neuropsychiatric symptoms in PPA in our study were more frequent than previously reported. Furthermore, the distress index of the NPI was not only correlated with the severity of the neuropsychiatric symptoms but also reflected the overall burden on the caregivers in the PPA group.
引用
收藏
页码：52 / 62
页数：11
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