Cross-Reactivity Assessment of Vaccine-Derived SARS-CoV-2 T Cell Responses against BA.2.86 and JN.1

被引:8
|
作者
Sohail, Muhammad Saqib [1 ]
Ahmed, Syed Faraz [2 ,3 ]
Quadeer, Ahmed Abdul [2 ]
Mckay, Matthew R. [2 ,3 ]
机构
[1] Hong Kong Univ Sci & Technol, Dept Elect & Comp Engn, Hong Kong, Peoples R China
[2] Univ Melbourne, Dept Elect & Elect Engn, Parkville, Vic 3010, Australia
[3] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic 3000, Australia
来源
VIRUSES-BASEL | 2024年 / 16卷 / 03期
关键词
SARS-CoV-2; COVID-19; BA.2.86; JN.1; T cell epitopes; immune escape; mutations; vaccines; IDENTIFICATION; EPITOPE; INFECTIVITY;
D O I
10.3390/v16030473
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The SARS-CoV-2 Omicron sub-variants BA.2.86 and JN.1 contain multiple mutations in the spike protein that were not present in previous variants of concern and Omicron sub-variants. Preliminary research suggests that these variants reduce the neutralizing capability of antibodies induced by vaccines, which is particularly significant for JN.1. This raises concern as many widely deployed COVID-19 vaccines are based on the spike protein of the ancestral Wuhan strain of SARS-CoV-2. While T cell responses have been shown to be robust against previous SARS-CoV-2 variants, less is known about the impact of mutations in BA.2.86 and JN.1 on T cell responses. We evaluate the effect of mutations specific to BA.2.86 and JN.1 on experimentally determined T cell epitopes derived from the spike protein of the ancestral Wuhan strain and the spike protein of the XBB.1.5 strain that has been recommended as a booster vaccine. Our data suggest that BA.2.86 and JN.1 affect numerous T cell epitopes in spike compared to previous variants; however, the widespread loss of T cell recognition against these variants is unlikely.
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页数:10
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