Chrysin, The Flavonoid Molecule of Antioxidant Interest

被引:14
|
作者
Mohammed, Hamdoon A. [1 ,2 ]
Sulaiman, Ghassan M. [3 ]
Albukhaty, Salim [4 ]
Al-Saffar, Ali Z. [5 ]
Elshibani, Fatma A. [6 ,7 ]
Ragab, Ehab A. [2 ]
机构
[1] Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Qasim 51452, Saudi Arabia
[2] Al Azhar Univ, Fac Pharm, Dept Pharmacognosy & Med Plants, Cairo 11371, Egypt
[3] Univ Technol Baghdad, Dept Appl Sci, Baghdad 10066, Iraq
[4] Univ Misan, Coll Sci, Dept Chem, Maysan 62001, Iraq
[5] Al Nahrain Univ, Coll Biotechnol, Dept Mol & Med Biotechnol, Baghdad, Iraq
[6] Univ Benghazi, Fac Pharm, Dept Pharmacognosy, Benghazi, Libya
[7] Assalam Int Univ, Fac Pharm, Dept Pharmacognosy, Benghazi, Libya
来源
CHEMISTRYSELECT | 2023年 / 8卷 / 48期
关键词
Anticancer; Cytotoxicity; Chrysin, 5,7-dihydroxyflavone, antioxidant; in vitro antioxidant; Nanotechnology; OXIDATIVE STRESS; XANTHINE-OXIDASE; CYTOTOXIC ACTIVITIES; IN-VITRO; NANOPARTICLES; ATTENUATION; METABOLISM; INFLAMMATION; INHIBITION; COMPLEX;
D O I
10.1002/slct.202303306
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Chrysin, the natural bioactive flavone compound, has been identified in several edible materials such as honey, propolis, and passionflower with numerous biological potentials and pharmaceutical effects including antitumor, anti-inflammatory, antiviral and antioxidant. The compound has been reported to have lower in vitro antioxidant activity compared to other flavone-based structures such as quercetin, luteolin, and myricetin, which is mostly attributed to the higher hydroxylation and the presence of conjugated en-diol structures in these flavonoids and the lack of these structural features in chrysin. On the contrary to the in vitro antioxidant effect of chrysin, the compound has exerted remarkable in vivo antioxidant activities in several models related to the liver, brain, heart, kidneys, and other soft tissues. The current review includes a discussion of the in vivo and in vitro antioxidant activity of chrysin compared to other common flavonoids. The study also covers subjects linked to chrysin antioxidants, such as its metabolism, bioavailability, and current formulations that aim to increase chrysin antioxidant impact and overcome its low bioavailability.
引用
收藏
页数:15
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