Les virus oncolytiques : acteurs et vecteurs de protéines thérapeutiques contre les tumeurs

被引：0
|
作者：
Houel, Ana [1 ,2 ,3 ,4 ]
Foloppe, Johann [4 ]
机构：
[1] Sorbonne Univ, UMRS 1 135, Paris, France
[2] INSERM, U1135, Paris, France
[3] Sorbonne Univ, Fac Med, Ctr Immunol & Malad Infect Cimi, Equipe Microenvironm Immunitaire & Immunotherapie, Paris, France
[4] Transgene SA, Illkirch Graffenstade, France
来源：
M S-MEDECINE SCIENCES | 2023年 / 39卷 / 11期
关键词：
SUICIDE GENE; IN-VIVO; ADENOVIRUS; TUMORS; EXPRESSION; ANTIBODIES; RESPONSES; EFFICACY; DELIVERY; THERAPY;
D O I：
10.1051/medsci/2023161
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The discovery of the unique ability of certain viruses to specifically target cancer cells has led to significant advancements in cancer immunotherapy research. In addition to inducing specific lysis of cancer cells, oncolytic viruses (OV) have been genetically modified to express molecules of interest within the tumor bed. The use of OV as vectors for therapeutic molecules has allowed to enhance antitumor responses while limiting the adverse effects associated with systemic administration of the molecule. Other studies are currently focused on delaying the neutralization and clearance of the virus by the host's immune system and improving its delivery insight tumors.
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页码：845 / 854
页数：10
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