Palladium-catalyzed bicyclization of alkynyl aryl iodide with allenyl malonates

被引：4
|
作者：
Zhou, Ping-Xin [1 ]
Liu, Yang [1 ]
Du, Xueyan [1 ]
Liu, Ning [1 ]
Li, Kexin [2 ]
Wu, Yuji [1 ]
Feng, Wang [1 ]
Liu, Xu [2 ]
Kong, Yingying [1 ]
机构：
[1] Xinxiang Med Univ, Sch Basic Med Sci, Xinxiang 453003, Henan, Peoples R China
[2] Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2023年 / 10卷 / 21期
关键词：
COUPLING-CYCLIZATION REACTION; TOSYLHYDRAZONE INSERTION REACTION; STEREOSELECTIVE-SYNTHESIS; N-TOSYLHYDRAZONES; NUCLEOPHILIC FUNCTIONALITY; SELECTIVE FORMATION; CASCADE REACTIONS; ACCESS; BONDS; REGIOSELECTIVITY;
D O I：
10.1039/d3qo01169k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed highly regio- and stereoselective reaction of alkynyl aryl iodide with allenyl malonates was realized to afford a series of bicyclic compounds. The cascade process involves intramolecular carbopalladation of internal alkynes/intermolecular carbopalladation of allenes/cyclization. This new approach has good functional group compatibility and broad substrate scope.
引用
收藏
页码：5451 / 5456
页数：6
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