Long-Term Outcome of Lower Extremity Bypass Surgery in Diabetic and Non-Diabetic Patients with Critical Limb-Threatening Ischaemia in Germany

被引:1
|
作者
Surmann, Johanna [1 ]
Meyer, Philipp [1 ]
Epple, Jasmin [2 ]
Schmitz-Rixen, Thomas [3 ]
Boeckler, Dittmar [1 ]
Grundmann, Reinhart T. [4 ]
Hinterseher, Irene
El Hage, Racha
机构
[1] Univ Hosp Heidelberg, Dept Vasc & Endovascular Surg, D-69120 Heidelberg, Germany
[2] Univ Hosp Frankfurt Main, Dept Vasc & Endovascular Surg, D-60596 Frankfurt, Germany
[3] Goethe Univ Frankfurt, Dept Vasc & Endovascular Surg, D-60629 Frankfurt, Germany
[4] German Soc Vasc Surg & Vasc Med, German Inst Vasc Healthcare Res DIGG, D-10115 Berlin, Germany
关键词
bypass surgery; open revascularisation; diabetes; critical limb-threatening ischaemia; peripheral artery disease; long-term survival; major amputation; INFRAINGUINAL BYPASS; REVASCULARIZATION;
D O I
10.3390/biomedicines12010038
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Aim: To present the short- and long-term outcomes of lower extremity bypass (LEB) surgery in patients with critical limb-threatening ischaemia (CLTI), comparing diabetic (DM) and non-diabetic (non-DM) patients. Methods: Retrospective analysis of anonymised data from a nationwide health insurance company (AOK). Data from 22,633 patients (DM: n = 7266; non-DM: n = 15,367; men: n = 14,523; women: n = 8110; mean patient age: 72.5 years), who underwent LEB from 2010 to 2015, were analysed. The cut-off date for follow-up was December 31, 2018 (mean follow-up period: 55 months). Results: Perioperative mortality was 10.0% for DM and 8.2% for non-DM (p < 0.001). Patients with crural/pedal bypasses (n = 8558) had a significantly higher perioperative mortality (10.3%) than those with above-the-knee (n = 7246; 5.8%; p < 0.001) and below-the-knee bypasses (n = 6829; 8.9%; p = 0.003). The 9-year survival rates in DM patients were significantly worse, at 21.5%, compared to non-DM, at 31.1% (p < 0.001). This applied to both PAD stage III (DM: 34.4%; non-DM: 45.7%; p < 0.001) and PAD stage IV (DM: 18.5%; non-DM: 25.0%; p < 0.001). Patients with crural/pedal bypasses had a significantly inferior survival rate (25.5%) compared to those with below-the-knee (27.7%; p < 0.001) and above-the-knee bypasses (31.7%; p < 0.001). Conclusion: Perioperative and long-term outcomes regarding survival and major amputation rate for CLTI patients undergoing LEB are consistently worse for DM patients compared to non-DM patients.
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页数:10
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