Molecular Mechanisms Responsible for Mesenchymal Stem Cell-Based Modulation of Obstructive Sleep Apnea

被引：0
|
作者：
Zdravkovic, Marija [1 ,2 ]
Harrell, Carl Randall [3 ]
Jakovljevic, Vladimir [4 ,5 ]
Djonov, Valentin [6 ]
Volarevic, Vladislav [7 ,8 ]
机构：
[1] Univ Belgrade, Fac Med, Dr Subot 8, Belgrade 11000, Serbia
[2] Univ Med Ctr Bezanijska Kosa, Dept Cardiol, Dr Zoza Matea bb, Belgrade 11080, Serbia
[3] Regenerat Proc Plant LLC, 34176 US Highway 19 N, Palm Harbor, FL 34684 USA
[4] Univ Kragujevac, Fac Med Sci, Ctr Excellence Redox Balance Res Cardiovasc & Meta, Dept Physiol, 69 Svetozar Markov St, Kragujevac 34000, Serbia
[5] Univ IM Sechenov, Dept Human Pathol, Moscow State Med 1, Trubetskaya St 8,Str 2, Moscow 119991, Russia
[6] Univ Bern, Inst Anat, Baltzerstr 2, CH-3012 Bern, Switzerland
[7] Univ Kragujevac, Fac Med Sci, Dept Genet, 69 Svetozar Markov St, Kragujevac 34000, Serbia
[8] Univ Kragujevac, Fac Med Sci, Dept Microbiol & Immunol, 69 Svetozar Markov St, Kragujevac 34000, Serbia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 04期
关键词：
mesenchymal stem cells; obstructive sleep apnea; cell-based therapy; immunomodulation; neovascularization; INTERLEUKIN-1 RECEPTOR ANTAGONIST; ENDOTHELIAL-CELLS; STROMAL CELLS; DIFFERENTIATION; INFLAMMATION;
D O I：
10.3390/ijms24043708
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mesenchymal stem cells (MSCs) are adult stem cells that reside in almost all postnatal tissues where, due to the potent regenerative, pro-angiogenic and immunomodulatory properties, regulate tissue homeostasis. Obstructive sleep apnea (OSA) induces oxidative stress, inflammation and ischemia which recruit MSCs from their niches in inflamed and injured tissues. Through the activity of MSC-sourced anti-inflammatory and pro-angiogenic factors, MSCs reduce hypoxia, suppress inflammation, prevent fibrosis and enhance regeneration of damaged cells in OSA-injured tissues. The results obtained in large number of animal studies demonstrated therapeutic efficacy of MSCs in the attenuation of OSA-induced tissue injury and inflammation. Herewith, in this review article, we emphasized molecular mechanisms which are involved in MSC-based neo-vascularization and immunoregulation and we summarized current knowledge about MSC-dependent modulation of OSA-related pathologies.
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页数：11
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