[3+2] Cascade Ring-Closing/Ring-Opening Strategy: Access to N-Indene-Tethered Amino Alcohols

被引：3

作者：

Mondal, Imtiaj ^{[1
]}

Roy, Shantonu ^{[1
]}

Naskar, Koushik ^{[1
]}

Karmakar, Sudip ^{[1
]}

Chowdhury, Moumita ^{[1
]}

Deb, Indubhusan ^{[1
]}

机构：

[1] Indian Inst Chem Biol, Organ & Med Chem Div, Kolkata 700032, India

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 46期

关键词：

CATALYZED C-H; NITROALKENES; LIGANDS; MILD; ARYL;

D O I：

10.1021/acs.orglett.3c02975

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented atom-economic redox neutral regioselective Rh-(III)-catalyzed cascade [3+2] annulation of 2-aryl oxazoline with alpha,beta-unsaturated nitro olefins has been accomplished, furnishing a novel set of nitro-functionalized indene-tethered amino alcohols through a synergistic ring-closing/ring-opening strategy via the formation of two new C-C bonds and the regioselective cleavage of the C2-O bond of oxazoline under silver free mild reaction conditions with a broad substrate scope.

引用

页码：8199 / 8204

页数：6

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