[3+2] Cascade Ring-Closing/Ring-Opening Strategy: Access to N-Indene-Tethered Amino Alcohols

被引:3
|
作者
Mondal, Imtiaj [1 ]
Roy, Shantonu [1 ]
Naskar, Koushik [1 ]
Karmakar, Sudip [1 ]
Chowdhury, Moumita [1 ]
Deb, Indubhusan [1 ]
机构
[1] Indian Inst Chem Biol, Organ & Med Chem Div, Kolkata 700032, India
关键词
CATALYZED C-H; NITROALKENES; LIGANDS; MILD; ARYL;
D O I
10.1021/acs.orglett.3c02975
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An unprecedented atom-economic redox neutral regioselective Rh-(III)-catalyzed cascade [3+2] annulation of 2-aryl oxazoline with alpha,beta-unsaturated nitro olefins has been accomplished, furnishing a novel set of nitro-functionalized indene-tethered amino alcohols through a synergistic ring-closing/ring-opening strategy via the formation of two new C-C bonds and the regioselective cleavage of the C2-O bond of oxazoline under silver free mild reaction conditions with a broad substrate scope.
引用
收藏
页码:8199 / 8204
页数:6
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