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[3+2] Cascade Ring-Closing/Ring-Opening Strategy: Access to N-Indene-Tethered Amino Alcohols
被引:3
|作者:
Mondal, Imtiaj
[1
]
Roy, Shantonu
[1
]
Naskar, Koushik
[1
]
Karmakar, Sudip
[1
]
Chowdhury, Moumita
[1
]
Deb, Indubhusan
[1
]
机构:
[1] Indian Inst Chem Biol, Organ & Med Chem Div, Kolkata 700032, India
关键词:
CATALYZED C-H;
NITROALKENES;
LIGANDS;
MILD;
ARYL;
D O I:
10.1021/acs.orglett.3c02975
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
An unprecedented atom-economic redox neutral regioselective Rh-(III)-catalyzed cascade [3+2] annulation of 2-aryl oxazoline with alpha,beta-unsaturated nitro olefins has been accomplished, furnishing a novel set of nitro-functionalized indene-tethered amino alcohols through a synergistic ring-closing/ring-opening strategy via the formation of two new C-C bonds and the regioselective cleavage of the C2-O bond of oxazoline under silver free mild reaction conditions with a broad substrate scope.
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页码:8199 / 8204
页数:6
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