Systemic Lupus erythematosus: Biological Effects of Iberdomide

被引：0
|
作者：
Brudermanns, Britta
机构：
来源：
AKTUELLE RHEUMATOLOGIE | 2023年 / 48卷 / 02期
关键词：
D O I：
10.1055/a-1950-2783
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Systemischen Lupus erythematodes (SLE) wird durch Gene der Immunresponse-Signalwege und dem Major Histocompatibility Complex Klasse I und II beeinflusst. Iberdomid ist ein hochaffiner Cereblon-Ligand, der den proteasomalen Abbau der Transkriptionsfaktoren Ikaros (IKZF1) und Aiolos (IKZF3) fordert. P. E. Lipsky und Kollegen untersuchten nun die Pharmakodynamik und Pharmakokinetik von oral verabreichtem Iberdomid bei Patienten mit SLE.
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页码：100 / 100
页数：1
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