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Guangzhou Med Univ, Natl Clin Res Ctr Resp Dis, Guangzhou Inst Resp Hlth,Affiliated Hosp 1, State Key Lab Resp Dis,Dept Allergy & Clin Immuno, Guangzhou 510120, Guangdong, Peoples R China Guangzhou Med Univ, Natl Clin Res Ctr Resp Dis, Guangzhou Inst Resp Hlth,Affiliated Hosp 1, State Key Lab Resp Dis,Dept Allergy & Clin Immuno, Guangzhou 510120, Guangdong, Peoples R China