A convenient protocol for a zinc-catalysed synthesis of electron-poor indoles

被引：0
|
作者：
Medici, F. [1 ]
Montinari, F. [1 ]
Donato, E. [1 ]
Raimondi, L. [1 ]
Benaglia, M. [1 ]
机构：
[1] Univ Milan, Chem Dept, Via Camillo Golgi 19, I-20133 Milan, Italy
来源：
TETRAHEDRON LETTERS | 2023年 / 116卷
关键词：
Indole; Cyclisation; Zinc; API precursor; Alkynyl group; 2-ALKYNYLANILINES; SCAFFOLD;
D O I：
10.1016/j.tetlet.2023.154340
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient catalytic protocol for the synthesis of electron-poor indoles was envisioned. A cyclisation reaction of electron-deficient 2-(alkynyl)-anilines, catalysed by Zn(II) salts, was successfully developed and applied to the synthesis of an API precursor. A two-step one-pot procedure starting from aniline derivatives was successfully developed. The use of a readily available, non-noble metal further enhanced the value of the protocol. (c) 2023 Elsevier Ltd. All rights reserved.
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页数：4
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