Hepatitis B virus reactivation after ibrutinib treatment

被引：0

作者：

Alventosa Mateu, Carlos ^{[1
]}

Urquijo Ponce, Juan Jose ^{[1
]}

Mena Duran, Armando ^{[2
]}

Latorre Sanchez, Mercedes ^{[1
]}

Castello Miralles, Inmaculada ^{[1
]}

Linares Garcia, Mariano ^{[2
]}

Diago, Moises ^{[1
]}

机构：

[1] Univ Valencia, Hepatol Unit, Valencia, Spain

[2] Univ Valencia, Consorcio Hosp Gen, Hematol Dept, Valencia, Spain

来源：

REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS | 2024年 / 116卷 / 01期

关键词：

Hepatitis B virus; Reactivation; Ibrutinib; Prophylaxis;

D O I：

10.17235/reed.2023.9587/2023

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

New immunosuppressive and antineoplastic drugs are becoming both more numerous and more widely used, even during several years. Most of them present a low-moderate risk of hepatitis B virus (HBV) reactivation in HBsAg-negative and anti-HBc-positive patients. However, their reactivation capacity has not been clearly studied. We present the clinical case of a patient with these serological characteristics who, after 5 years of treatment with ibrutinib for chronic lymphocytic leukaemia, developed VHB reactivation, which was controlled with tenofovir. The occurrence of this event with drugs such as ibrutinib may lead to changes in HBV reactivation prophylaxis.

引用

页码：43 / 43

页数：1

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