Opto-electronic feedback control of membrane potential for real-time control of action potentials

被引：2

作者：

Ordog, Balazs ^{[1
]}

De Coster, Tim ^{[1
]}

Dekker, Sven O. ^{[1
]}

Bart, Cindy I. ^{[1
]}

Zhang, Juan ^{[1
]}

Boink, Gerard J. J. ^{[2
,3
]}

Bax, Wilhelmina H. ^{[1
]}

Deng, Shanliang ^{[1
,4
]}

den Ouden, Bram L. ^{[1
,4
]}

de Vries, Antoine A. F. ^{[1
]}

Pijnappels, Daniel A. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Lab Expt Cardiol,Dept Cardiol, NL-2333 ZA Leiden, Netherlands

[2] Univ Amsterdam, Dept Cardiol, Amsterdam Cardiovasc Sci, Dept Cardiol,Location AMC, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Amsterdam, Dept Med Biol, Amsterdam UMC, Locat AMC, NL-1105 AZ Amsterdam, Netherlands

[4] Delft Univ Technol, Dept Microelect, NL-2628 CD Delft, Netherlands

来源：

CELL REPORTS METHODS | 2023年 / 3卷 / 12期

基金：

欧洲研究理事会;

关键词：

CLOSED-LOOP; OPTOGENETIC CONTROL; HEART-FAILURE; CLAMP;

D O I：

10.1016/j.crmeth.2023.100671

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

To unlock new research possibilities by acquiring control of action potential (AP) morphologies in excitable cells, we developed an opto-electronic feedback loop-based system integrating cellular electrophysiology, real-time computing, and optogenetic approaches and applied it to monolayers of heart muscle cells. This allowed accurate restoration and preservation of cardiac AP morphologies in the presence of electrical perturbations of different origin in an unsupervised, self-regulatory manner, without any prior knowledge of the disturbance. Moreover, arbitrary AP waveforms could be enforced onto these cells. Collectively, these results set the stage for the refinement and application of opto-electronic control systems to enable in-depth investigation into the regulatory role of membrane potential in health and disease.

引用

页数：18

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