Aim: The current study evaluated UTI among Saudi children in the Northern Border region regarding their predisposing factors, causative uropathogens and antibiotic sensitivity.Material and Methods: The retrospective study enrolled children (0-14 years old) who attended to Arar Maternity & Pediatric Hospital from in 2017-2022 with discharge a final discharge diagnosis as of UTI according to following the American Academy of Pediatrics (AAP) Clinical Practice Guidelines.Results: UTI was reported in 606 cases during the study period. It was more prevalent among boys' male infants under one year of below the age of one year, while in girls, it was more common in girls at the age above 6 years. High-grade fever, dysuriea, foul-smelling urine and loin pain were the most commonest presentations. Recurrent UTI was reported in 30.4% of UTI cases. Constipation was the most commonest reported risk factors (32.7% of the diagnosed children). Structural anomalies were the most commonest predisposing factors among recurrent UTI cases. Escherichia coli (E.coli) and Klebsiella were the most commonest causative organisms (56.4 %, and 28.9 % of cases, respectively). Culture and sensitivity test data showed that E.coli were most sensitive to IMP, Ceftriaxone (CTR) & TZP in about 98.5 %, 84.8 % and 74.6 % of cases, respectively. While Klebsiella was sensitive to IMP, TZP & Amikacin (AMK) in about 42.3 %, 34.3 % and 33.7 % of cases, respectively.Discussion: The Ccurrent data showed that UTI is a common health problem among children in the Northern Border region and provide insights give data intoabout its uropathogens and their antibiotic response characteristics, which can help in management plans.