Liquid-liquid phase separation drug aggregate: Merit for oral delivery of amorphous solid dispersions

被引：18

作者：

Zhao, Peixu ^{[1
]}

Han, Wen ^{[1
]}

Shu, Yecheng ^{[1
]}

Li, Mo ^{[2
]}

Sun, Yichi ^{[3
]}

Sui, Xiaofan ^{[2
]}

Liu, Bingyang ^{[1
]}

Tian, Baocheng ^{[4
]}

Liu, Yanhua ^{[5
]}

Fu, Qiang ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Wuya Coll Innovat, 103 Wenhua Rd, Shenyang 110016, Peoples R China

[2] Liaoning Inst Drug Control, 7 Chongshan West Rd, Shenyang 110016, Peoples R China

[3] Shenyang Pharmaceut Univ, Sch Pharm, 103 Wenhua Rd, Shenyang 110016, Peoples R China

[4] Binzhou Med Univ, Sch Pharm, 346 Guanhai Rd, Yantai 264003, Peoples R China

[5] Ningxia Med Univ, Dept Pharmaceut, 1160 Shengli St, Yinchuan 750004, Peoples R China

来源：

JOURNAL OF CONTROLLED RELEASE | 2023年 / 353卷

基金：

中国国家自然科学基金;

关键词：

Amorphous solid dispersion; Drug aggregate; Liquid-liquid phase separation; Oral drug delivery; Permeability enhancement; Unstirred water layer; SUPERSATURATED AQUEOUS-SOLUTIONS; MOLECULAR MOBILITY; IN-VITRO; CRYSTALLIZATION RATES; DISSOLUTION; WATER; BIOAVAILABILITY; PHARMACEUTICALS; SOLUBILITY; NIFEDIPINE;

D O I：

10.1016/j.jconrel.2022.11.033

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

As a promising strategy, amorphous solid dispersion has been extensively employed in improving the oral bioavailability of insoluble drugs. Despite the numerous advantages, the problems associated with supersatu-ration stability limit its further application. Recently, the formation and stability of the liquid-liquid phase separation drug aggregate (LLPS-DA) have been found to be vital for supersaturation maintenance. An in-depth review of LLPS-DA was required to further explore the supersaturation maintenance mechanism in vivo. Hence, this study aimed to present a short review to introduce the LLPS-DA, highlight the in vivo advantages for oral administration, and discuss the prospects to help understand the in vivo behavior of LLPS-DA.

引用

页码：42 / 50

页数：9

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