Long-term benefit of DAAs on gut dysbiosis and microbial translocation in HCV-infected patients with and without HIV coinfection

被引:2
|
作者
Chuaypen, Natthaya [1 ]
Jinato, Thananya [1 ,2 ]
Avihingsanon, Anchalee [3 ]
Nookaew, Intawat [4 ]
Tanaka, Yasuhito [5 ]
Tangkijvanich, Pisit [1 ]
机构
[1] Chulalongkorn Univ, Fac Med, Ctr Excellence Hepatitis & Liver Canc, Dept Biochem, Bangkok, Thailand
[2] Chulalongkorn Univ, Fac Med, Philosophy Program Med Sci, Grad Affairs, Bangkok, Thailand
[3] HIV Netherlands Australia Thailand Res Collaborat, Bangkok, Thailand
[4] Univ Arkansas Med Sci, Coll Med, Dept Biomed Informat, Little Rock, AR USA
[5] Kumamoto Univ, Dept Gastroenterol & Hepatol, Div Integrated Med & Pharmaceut Sci, Kumamoto, Japan
关键词
HEPATITIS-C;
D O I
10.1038/s41598-023-41664-7
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Long-term effect of Direct-acting antivirals (DAAs) on gut microbiota, short-chain fatty acids (SCFAs) and microbial translocation in patients with hepatitis C virus (HCV) infection who achieve sustained virological response (SVR) were limited. A longitudinal study of 50 patients with HCV monoinfection and 19 patients with HCV/HIV coinfection received DAAs were conducted. Fecal specimens collected at baseline and at week 72 after treatment completion (FUw72) were analyzed for 16S rRNA sequencing and the butyryl-CoA:acetateCoA transferase (BCoAT) gene expression using real-time PCR. Plasma lipopolysaccharide binding protein (LBP) and intestinal fatty acid binding protein (I-FABP) were quantified by ELISA assays. SVR rates in mono- and coinfected patients were comparable (94% vs. 100%). The improvement of gut dysbiosis and microbial translocation was found in responders but was not in non-responders. Among responders, significant restoration of alpha-diversity, BCoAT and LBP were observed in HCV patients with low-grade fibrosis (F0-F1), while HCV/HIV patients exhibited partial improvement at FUw72. I-FABP did not decline significantly in responders. Treatment induced microbiota changes with increasing abundance of SCFAs-producing bacteria, including Blautia, Fusicatenibacter, Subdoligranulum and Bifidobacterium. In conclusion, long-term effect of DAAs impacted the restoration of gut dysbiosis and microbial translocation. However, early initiation of DAAs required for an alteration of gut microbiota, enhanced SCFAs-producing bacteria, and could reduce HCV-related complications.
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页数:13
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