Correlation between Thyroid Responses and Inflammatory Cytokines in Critically Ill COVID-19 Patients

被引:1
|
作者
Figueras Castilla, Albert [1 ]
Ballesteros Vizoso, Maria A. [2 ]
Iglesias Coma, Amanda [3 ,4 ]
Barcelo, Antonia [2 ,3 ]
Barea-Mendoza, Jesus A. [5 ]
Argente del Castillo, Paula [2 ]
Guardiola, Begona [1 ]
Perez-Barcena, Jon [1 ,3 ]
Llompart-Pou, Juan A. A. [1 ,3 ]
机构
[1] Hosp Univ Son Espases, Serv Med Intens, Palma De Mallorca 07120, Spain
[2] Hosp Univ Son Espases, Serv Anal Clin, Palma De Mallorca 07120, Spain
[3] Inst Invest Sanitaria Illes Balears IdISBa, Palma De Mallorca 07120, Spain
[4] Inst Salud Carlos III CIBERES, Ctr Invest Biomed Red Enfermedades Respiratorias, Madrid 28029, Spain
[5] Hosp Univ 12 Octubre, Serv Med Intens, UCI Trauma & Emergencias, Madrid 28041, Spain
关键词
COVID-19; thyroid hormones; cytokines; organ failure;
D O I
10.3390/biomedicines11010026
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mechanisms involved in thyroid dysfunction in critically ill coronavirus disease 2019 (COVID-19) patients are not clear. Our objective was to correlate the thyroid response with the pro- and anti-inflammatory cytokines profile in critically ill COVID-19 patients. This was a prospective single-center study. We studied the relationship between continuous variables by using Pearson correlation and simple linear regression. Multiple logistic regression analysis was performed to analyze the factors independently associated with mortality. Seventy-eight patients were included in the study at intensive care unit (ICU) admission and 72 had a measurement of the thyroid and inflammatory profile at day 5. No significant correlations were found between thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) and inflammatory cytokines at ICU admission. At day 5, fT4, was inversely correlated with IL-10 (p = 0.035). IL-10 was associated with maximum lactate (p < 0.001) and SOFA score values (p = 0.012). The multiple logistic regression analysis showed that there was a significant relationship between IL-10 (day 5) and in-hospital mortality after adjusting by age and severity of illness. In conclusion, we found that the thyroid hormone profile and inflammatory cytokines had a weak correlation at ICU admission. Associations of interest between fT4 and IL-10 were found at day 5. IL-10 at day 5 was found to be correlated with low fT4 and markers of organ failure and death.
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页数:9
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