Advances in research on microbial conjugated linoleic acid bioconversion

被引：10
|
作者：
Wu, Chen [1 ,2 ]
Chen, Haiqin [1 ,2 ]
Mei, Yongchao [1 ,2 ]
Yang, Bo [1 ,2 ]
Zhao, Jianxin [1 ,2 ,3 ]
Stanton, Catherine [4 ,5 ,6 ]
Chen, Wei [1 ,2 ,4 ]
机构：
[1] Jiangnan Univ, State Key Lab Food Sci & Resources, Wuxi 214122, Jiangsu, Peoples R China
[2] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China
[3] Jiangnan Univ, Natl Engn Res Ctr Funct Food, Wuxi 214122, Jiangsu, Peoples R China
[4] Jiangnan Univ, Int Joint Res Ctr Probiot & Gut Hlth, Wuxi 214122, Peoples R China
[5] Teagasc Food Res Ctr, Moorepk, Fermoy, Cork, Ireland
[6] Univ Coll Cork, APC Microbiome Ireland, Cork, Ireland
来源：
PROGRESS IN LIPID RESEARCH | 2024年 / 93卷
关键词：
Linoleic acid isomerase; Multienzymatic system; Catalytic mechanism; Biosynthesis; Fermented products; Functional foods; DOUBLE-BOND HYDRATASE; FUNCTIONAL STARTER CULTURE; POTENTIAL HEALTH-BENEFITS; HYDROXY FATTY-ACIDS; LACTOBACILLUS-ACIDOPHILUS; HETEROLOGOUS EXPRESSION; ARTHROBACTER-SIMPLEX; SUNFLOWER OIL; CLA CONTENT; MRS BROTH;
D O I：
10.1016/j.plipres.2023.101257
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Conjugated linoleic acid (CLA) is a functional food ingredient with prebiotic properties that provides health benefits for various human pathologies and disorders. However, limited natural CLA sources in animals and plants have led microorganisms like Lactobacillus and Bifidobacterium to emerge as new CLA sources. Microbial conversion of linoleic acid to CLA is mediated by linoleic acid isomerase and multicomponent enzymatic systems, with CLA production efficiency dependent on microbial species and strains. Additionally, complex factors like LA concentration, growth status, culture substrates, precursor type, prebiotic additives, and co-cultured microbe identity strongly influence CLA production and isomer composition. This review summarizes advances in the past decade regarding microbial CLA production, including bacteria and fungi. We highlight CLA production and potential regulatory mechanisms and discuss using microorganisms to enhance CLA content and nutritional value of fermented products. We also identify primary microbial CLA production bottlenecks and provide strategies to address these challenges and enhance production through functional gene and enzyme mining and downstream processing. This review aims to provide a reference for microbial CLA production and broaden the understanding of the potential probiotic role of microbial CLA producers.
引用
收藏
页数：15
相关论文
共 50 条
  • [21] Bioconversion of trans-11 C18:1 to conjugated linoleic acid in humans
    Turpeinen, AM
    Mutanen, M
    Aro, A
    Salminen, I
    Palmquist, DL
    Griinari, MJ
    FASEB JOURNAL, 2001, 15 (05): : A1090 - A1090
  • [22] Chemoenzymatic Conversion of Linoleic Acid into Conjugated Linoleic Acid
    Demir, Ayhan S.
    Talpur, Farah N.
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2010, 58 (03) : 1646 - 1652
  • [23] Enzymatic conversion of linoleic acid to conjugated linoleic acid
    Dunford, NT
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U28 - U28
  • [24] Bioconversion enhancement of conjugated linoleic acid by Lactobacillus plantarum using the culture media manipulation and numerical optimization
    Khosravi, Azin
    Safari, Mohammad
    Khodaiyan, Faramarz
    Gharibzahedi, Seyed Mohammad Taghi
    JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE, 2015, 52 (09): : 5781 - 5789
  • [25] Bioconversion enhancement of conjugated linoleic acid by Lactobacillus plantarum using the culture media manipulation and numerical optimization
    Azin Khosravi
    Mohammad Safari
    Faramarz Khodaiyan
    Seyed Mohammad Taghi Gharibzahedi
    Journal of Food Science and Technology, 2015, 52 : 5781 - 5789
  • [26] β-oxidation of conjugated linoleic acid isomers and linoleic acid in rats
    Sergiel, JP
    Chardigny, JM
    Sébédio, JL
    Berdeaux, O
    Juaneda, P
    Loreau, O
    Pasquis, B
    Noel, JP
    LIPIDS, 2001, 36 (12) : 1327 - 1329
  • [27] Conjugated linoleic acid (CLA)
    MacGibbon, AKH
    Rowan, AM
    PROCEEDINGS OF THE NUTRITION SOCIETY OF NEW ZEALAND, VOL 25, 2000, 25 : 85 - 94
  • [28] Conjugated linoleic acid in meat
    Govari, M.
    Vareltzis, P.
    JOURNAL OF THE HELLENIC VETERINARY MEDICAL SOCIETY, 2024, 75 (02):
  • [29] CLA (conjugated linoleic acid)
    Ide, Takashi
    JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI, 2006, 53 (08): : 447 - 447
  • [30] Conjugated linoleic acid metabolism
    Banni, S
    CURRENT OPINION IN LIPIDOLOGY, 2002, 13 (03) : 261 - 266
12345