Astroglial activation: Current concepts and future directions

被引：5
|
作者：
Edison, Paul [1 ,2 ]
机构：
[1] Imperial Coll London, Div Neurol, Dept Brain Sci, Fac Med, London, England
[2] Cardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, Cardiff, Wales
来源：
ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 04期
基金：
英国医学研究理事会;
关键词：
Alzheimer's disease; astrocytes; cognitive impairment; glial activation; AMYOTROPHIC-LATERAL-SCLEROSIS; GLIAL-CELL NUMBERS; NF-KAPPA-B; ALZHEIMERS-DISEASE; NEURONAL-ACTIVITY; ENDOPLASMIC-RETICULUM; ASTROCYTE REACTIVITY; AEROBIC GLYCOLYSIS; CALCIUM WAVES; DOUBLE-BLIND;
D O I：
10.1002/alz.13678
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Astrocytes are abundantly and ubiquitously expressed cell types with diverse functions throughout the central nervous system. Astrocytes show remarkable plasticity and exhibit morphological, molecular, and functional remodeling in response to injury, disease, or infection of the central nervous system, as evident in neurodegenerative diseases. Astroglial mediated inflammation plays a prominent role in the pathogenesis of neurodegenerative diseases. This review focus on the role of astrocytes as essential players in neuroinflammation and discuss their morphological and functional heterogeneity in the normal central nervous system and explore the spatial and temporal variations in astroglial phenotypes observed under different disease conditions. This review discusses the intimate relationship of astrocytes to pathological hallmarks of neurodegenerative diseases. Finally, this review considers the putative therapeutic strategies that can be deployed to modulate the astroglial functions in neurodegenerative diseases.
引用
收藏
页码：3034 / 3053
页数：20
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