Quinoline Hydrazide/Hydrazone Derivatives: Recent Insights on Antibacterial Activity and Mechanism of Action

被引:40
|
作者
Verma, Sangeeta [1 ]
Lal, Sukhbir [1 ]
Narang, Rakesh [1 ]
Sudhakar, Kalvatala [2 ]
机构
[1] Kurukshetra Univ, Inst Pharmaceut Sci, Kurukshetra 136119, India
[2] Lovely Profess Univ, Sch Pharmaceut Sci, Bengaluru 144402, India
关键词
antibacterial agents; drug resistance; DNA gyrase; metal complexes; quinoline hydrazide; hydrazone derivatives; SCHIFF-BASE HYDRAZONE; POTENTIAL ANTIMICROBIAL AGENTS; MIXED-LIGAND COMPLEXES; METAL-COMPLEXES; BIOLOGICAL EVALUATION; IN-SILICO; ACID; DOCKING; DESIGN; CU(II);
D O I
10.1002/cmdc.202200571
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Antibiotics are becoming gradually ineffective due to drug resistance, leading to greater difficulty in the treatment of infectious diseases. Therefore, the development of new chemical entities with different mechanisms of action is essential in the fight against resistant microorganisms. Various studies have shown that quinoline hydrazide/hydrazone derivatives possess several biological activities, such as antimalarial, antitubercular, anticancer, anti-inflammatory, and antimicrobial. Among these activities, the antibacterial activity of quinoline hydrazide/hydrazone derivatives is noteworthy. The synthetic flexibility of the quinoline ring has led to the development of a wide range of structurally diverse quinoline hydrazide/hydrazone derivatives, which can act at various bacterial targets such as DNA gyrase, glucosamine-6-phosphate synthase, enoyl ACP reductase, and 3-ketoacyl ACP reductase. This review emphasizes the antibacterial potential of various reported quinoline hydrazide/hydrazone derivatives based on substitution in the quinoline ring. The antibacterial activity of various metal-quinoline hydrazide/hydrazone complexes is also discussed. The aim of this review is to assemble and scrutinize the latest reports in this promising area of drug development.
引用
收藏
页数:22
相关论文
共 50 条
  • [31] Synthesis, Characterization and Anti-Cancer Activity of Hydrazide Derivatives Incorporating a Quinoline Moiety
    Bingul, Murat
    Tan, Owen
    Gardner, Christopher R.
    Sutton, Selina K.
    Arndt, Greg M.
    Marshall, Glenn M.
    Cheung, Belamy B.
    Kumar, Naresh
    Black, David StC.
    MOLECULES, 2016, 21 (07):
  • [32] Synthesis and radical scavenging activity of new phenolic hydrazone/hydrazide derivatives: Experimental and theoretical studies
    Boulebd, Houssem
    Zine, Yasmine
    Khodja, Imene Amine
    Mermer, Arif
    Demir, Adem
    Debache, Abdelmadjid
    JOURNAL OF MOLECULAR STRUCTURE, 2022, 1249
  • [33] Synthesis and antioxidant activity evaluations of melatonin based analogue indole-hydrazide/hydrazone derivatives
    AD Yılmaz
    H Shirinzadeh
    T Coban
    S Suzen
    S Ozden
    BMC Proceedings, 6 (Suppl 4)
  • [34] Antiprotozoal Activity of Benzoylthiourea Derivatives against Trypanosoma cruzi: Insights into Mechanism of Action
    Pereira, Patricia Morais Lopes
    Fernandes, Bruna Terci
    dos Santos, Vitoria Ribeiro
    Cabral, Weslei Roberto Correia
    Lovo-Martins, Maria Isabel
    Alonso, Lais
    Lancheros, Cesar Armando Contreras
    de Paula, Jessica Carreira
    Camargo, Priscila Goes
    Suzukawa, Helena Tiemi
    Alonso, Antonio
    Macedo Jr, Fernando
    Nakamura, Celso Vataru
    Tavares, Eliandro Reis
    Bispo, Marcelle de Lima Ferreira
    Yamauchi, Lucy Megumi
    Pinge-Filho, Phileno
    Yamada-Ogatta, Sueli Fumie
    PATHOGENS, 2023, 12 (08):
  • [35] Recent insights into the mechanism of action of glatiramer acetate
    Kala, Mrinalini
    Miravalle, Augusto
    Vollmer, Timothy
    JOURNAL OF NEUROIMMUNOLOGY, 2011, 235 (1-2) : 9 - 17
  • [36] Antibacterial Activity and Mechanism of Action of Bovine Lactoferricin Derivatives with Symmetrical Amino Acid Sequences
    Sun, Changbao
    Li, Yingying
    Cao, Songsong
    Wang, Haimei
    Jiang, Chenggang
    Pang, Shiyue
    Hussain, Muhammad Altaf
    Hou, Juncai
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (10)
  • [37] Design, Synthesis and Antibacterial Activity Studies of Novel Quinoline Carboxamide Derivatives
    Shivaraj, Yellappa
    Naveen, Malenahalli H.
    Vijayakumar, Giriyapura R.
    Kumar, Doyijode B. Aruna
    JOURNAL OF THE KOREAN CHEMICAL SOCIETY-DAEHAN HWAHAK HOE JEE, 2013, 57 (02): : 241 - 245
  • [38] Synthesis, characterization and antibacterial activity of benzimidazole derivatives carrying quinoline moiety
    Gowda, Janardhana
    Khader, A. M. A.
    Kalluraya, Balakrishna
    Hidayathulla, Syed
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2011, 50 (10): : 1491 - 1495
  • [39] Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity
    Mohareb, Rafat M.
    Fleita, Daisy H.
    Sakka, Ola K.
    MOLECULES, 2011, 16 (01): : 16 - 27
  • [40] Synthesis and Antibacterial Activity Evaluation of Guanidine Hydrazone Derivatives Containing Linear Alkanes
    Song Mingxia
    Zhu Yangnv
    Wang Shishuai
    Huang Yuping
    Deng Xianqing
    Huang Yushan
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2023, 43 (06) : 2163 - 2170