Spine Metastasis Is Associated with the Development of Brain Metastasis in Non-Small-Cell Lung Cancer Patients

被引:0
|
作者
Cha, Hyung-Keun [1 ]
Ryu, Woo-Kyung [1 ]
Lee, Ha-Young [2 ]
Kim, Hyun-Jung [1 ]
Ryu, Jeong-Seon [1 ]
Lim, Jun-Hyeok [1 ]
机构
[1] Inha Univ, Inha Univ Hosp, Coll Med, Dept Pulmonol,Internal Med, Incheon 22332, South Korea
[2] Inha Univ, Inha Univ Hosp, Coll Med, Dept Radiol, Incheon 22332, South Korea
来源
MEDICINA-LITHUANIA | 2024年 / 60卷 / 01期
关键词
brain metastasis; bone metastasis; spine metastasis; cerebrospinal fluid space; non-small-cell lung cancer; SURVIVAL; IMPACT; ALECTINIB; MODELS; ALK;
D O I
10.3390/medicina60010152
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and Objectives: The mechanisms involved in the development of brain metastasis (BM) remain elusive. Here, we investigated whether BM is associated with spine involvement in patients with non-small-cell lung cancer (NSCLC). Materials and Methods: A consecutive 902 patients with metastatic NSCLC were included from the Inha Lung Cancer Cohort. Patients with BM at diagnosis or subsequent BM development were evaluated for both spine involvement in NSCLC and anatomic proximity of BM to the cerebrospinal fluid (CSF) space. Results: At diagnosis, BM was found in 238 patients (26.4%) and bone metastasis was found in 393 patients (43.6%). In patients with bone metastasis, spine involvement was present in 280 patients. BM subsequently developed in 82 (28.9%) of 284 patients without BM at diagnosis. The presence of spine metastasis was associated with BM at diagnosis and subsequent BM development (adjusted odd ratios and 95% confidence intervals = 2.42 and 1.74-3.37, p < 0.001; 1.94 and 1.19-3.18, p = 0.008, respectively). Most patients with spine metastasis, either with BM at diagnosis or subsequent BM, showed BM lesions located adjacent (within 5mm) to the CSF space (93.8% of BM at the diagnosis, 100% of subsequent BM). Conclusions: These findings suggest that the presence of spine involvement is a risk factor for BM development in NSCLC patients with bone metastasis.
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页数:10
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