Kruppel-like factor 15 in liver diseases: Insights into metabolic reprogramming

被引：6
|
作者：
Chen, Hao [1 ,2 ]
Li, Lan-Lan [1 ,2 ]
Du, Yan [1 ,2 ]
机构：
[1] Anhui Med Univ, Dept Pharm, Affiliated Hosp 1, Hefei, Anhui, Peoples R China
[2] State Adm Tradit Chinese Med, Grade 3 Pharmaceut Chem Lab, Hefei, Anhui, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷
关键词：
liver diseases; metabolic reprogramming; Kruppel-like factor 15; gluconeogenesis; lipid; amino acid catabolism; bile acids; endobiotic metabolism and xenobiotic metabolism; HEPATITIS-B-VIRUS; TRANSCRIPTION FACTORS; GENE-EXPRESSION; CELL-PROLIFERATION; FACTOR FAMILY; ONCOSTATIN-M; BILE-ACIDS; KLF15; GLUCONEOGENESIS; GLUCOSE;
D O I：
10.3389/fphar.2023.1115226
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Liver diseases, characterized by metabolic disorder, have become a global public health problem with high morbidity and mortality. Kruppel-like factor 15 (KLF15) is a zinc-finger transcription factor mainly enriched in liver. Increasing evidence suggests that hepatic KLF15 is activated rapidly during fasting, and contributes to the regulation of gluconeogenesis, lipid, amino acid catabolism, bile acids, endobiotic and xenobiotic metabolism. This review summarizes the latest advances of KLF15 in metabolic reprogramming, and explore the function of KLF15 in acute liver injury, hepatitis B virus, and autoimmune hepatitis. which aims to evaluate the potential of KLF15 as a therapeutic target and prognostic biomarker for liver diseases.
引用
收藏
页数：11
相关论文
共 50 条
  • [41] Kruppel-Like Factor 15 Regulates the Circadian Susceptibility to Ischemia Reperfusion Injury in the Heart
    Li, Le
    Li, Hui
    Tien, Chih-Liang
    Jain, Mukesh K.
    Zhang, Lilei
    CIRCULATION, 2020, 141 (17) : 1427 - 1429
  • [42] Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation
    Haldar, Saptarsi M.
    Jeyaraj, Darwin
    Anand, Priti
    Zhu, Han
    Lu, Yuan
    Prosdocimo, Domenick A.
    Eapen, Betty
    Kawanami, Daiji
    Okutsu, Mitsuharu
    Brotto, Leticia
    Fujioka, Hisashi
    Kerner, Janos
    Rosca, Mariana G.
    McGuinness, Owen P.
    Snow, Rod J.
    Russell, Aaron P.
    Gerber, Anthony N.
    Bai, Xiaodong
    Yan, Zhen
    Nosek, Thomas M.
    Brotto, Marco
    Hoppel, Charles L.
    Jain, Mukesh K.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (17) : 6739 - 6744
  • [43] Emerging Roles of Kruppel-Like Factor 6 and Kruppel-Like Factor 6 Splice Variant 1 in Ovarian Cancer Progression and Treatment
    DiFeo, Analisa
    Narla, Goutham
    Martignetti, John A.
    MOUNT SINAI JOURNAL OF MEDICINE, 2009, 76 (06): : 557 - 566
  • [44] Kruppel-like Factor 15 Activates Hepatitis B Virus Gene Expression and Replication
    Zhou, Jie
    Tan, Thomas
    Tian, Yongjun
    Zheng, Bojian
    Ou, J. -H. James
    Huang, Eric J.
    Yen, T. S. Benedict
    HEPATOLOGY, 2011, 54 (01) : 109 - 121
  • [45] The Kruppel-like factor KLF15 inhibits transcription of the adrenomedullin gene in adipocytes
    Nagare, Tomoki
    Sakaue, Hiroshi
    Takashima, Mototsugu
    Takahashi, Kazuhiro
    Gomi, Hideyuki
    Matsuki, Yasushi
    Watanabe, Eijiro
    Hiramatsu, Ryuji
    Ogawa, Wataru
    Kasuga, Masato
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 379 (01) : 98 - 103
  • [46] Kruppel-like factor 15 induces the development of mature hepatocyte-like cells from hepatoblasts
    Anzai, Kazuya
    Tsuruya, Kota
    Ida, Kinuyo
    Kagawa, Tatehiro
    Inagaki, Yutaka
    Kamiya, Akihide
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [47] Kruppel-like factor 15 induces the development of mature hepatocyte-like cells from hepatoblasts
    Kazuya Anzai
    Kota Tsuruya
    Kinuyo Ida
    Tatehiro Kagawa
    Yutaka Inagaki
    Akihide Kamiya
    Scientific Reports, 11
  • [48] Kruppel-like factor 4 regulates keratinocyte senescence
    Panatta, Emanuele
    Lena, Anna Maria
    Mancini, Mara
    Affinati, Michela
    Smirnov, Artem
    Annicchiarico-Petruzzelli, Margherita
    Piro, Maria Cristina
    Campione, Elena
    Bianchi, Luca
    Mazzanti, Cinzia
    Melino, Gerry
    Candi, Eleonora
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 499 (02) : 389 - 395
  • [49] The Role of Kruppel-like Factor 4 in Renal Fibrosis
    Ke, Ben
    Zhang, Afei
    Wu, Xianfeng
    Fang, Xiangdong
    FRONTIERS IN PHYSIOLOGY, 2015, 6
  • [50] Regulation of DNA repair by Kruppel-like factor 8
    Lu, Heng
    Hu, Liu
    Li, Tianshu
    Mukherjee, Debarati
    Lahiri, Satadru
    Wason, Melissa
    Yu, Lin
    Zhao, Jihe
    CANCER RESEARCH, 2012, 72
12345