Kruppel-like factor 15 in liver diseases: Insights into metabolic reprogramming

被引：6
|
作者：
Chen, Hao [1 ,2 ]
Li, Lan-Lan [1 ,2 ]
Du, Yan [1 ,2 ]
机构：
[1] Anhui Med Univ, Dept Pharm, Affiliated Hosp 1, Hefei, Anhui, Peoples R China
[2] State Adm Tradit Chinese Med, Grade 3 Pharmaceut Chem Lab, Hefei, Anhui, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷
关键词：
liver diseases; metabolic reprogramming; Kruppel-like factor 15; gluconeogenesis; lipid; amino acid catabolism; bile acids; endobiotic metabolism and xenobiotic metabolism; HEPATITIS-B-VIRUS; TRANSCRIPTION FACTORS; GENE-EXPRESSION; CELL-PROLIFERATION; FACTOR FAMILY; ONCOSTATIN-M; BILE-ACIDS; KLF15; GLUCONEOGENESIS; GLUCOSE;
D O I：
10.3389/fphar.2023.1115226
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Liver diseases, characterized by metabolic disorder, have become a global public health problem with high morbidity and mortality. Kruppel-like factor 15 (KLF15) is a zinc-finger transcription factor mainly enriched in liver. Increasing evidence suggests that hepatic KLF15 is activated rapidly during fasting, and contributes to the regulation of gluconeogenesis, lipid, amino acid catabolism, bile acids, endobiotic and xenobiotic metabolism. This review summarizes the latest advances of KLF15 in metabolic reprogramming, and explore the function of KLF15 in acute liver injury, hepatitis B virus, and autoimmune hepatitis. which aims to evaluate the potential of KLF15 as a therapeutic target and prognostic biomarker for liver diseases.
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页数：11
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