Urine soluble TLR4 levels may contribute to predict urinary tract infection in children: the UTILISE Study

被引：1

作者：

Aksu, Bagdagul ^{[1
,2
]}

Afonso, Alberto Caldas ^{[3
]}

Akil, Ipek ^{[4
]}

Alpay, Harika ^{[5
]}

Atmis, Bahriye ^{[6
,7
]}

Aydog, Ozlem ^{[8
]}

Bayazit, Aysun Karabay ^{[7
]}

Bayram, Meral Torun ^{[9
]}

Bilge, Ilmay ^{[10
]}

Bulut, Ipek Kaplan ^{[11
]}

Buyukkaragoz, Bahar ^{[12
]}

Comak, Elif ^{[13
]}

Demir, Belde Kasap ^{[14
,15
]}

Dincel, Nida ^{[16
]}

Donmez, Osman ^{[17
]}

Durmus, Mehmet Akif ^{[18
]}

Dursun, Hasan ^{[19
]}

Dusunsel, Ruhan ^{[20
]}

Duzova, Ali ^{[21
]}

Ertan, Pelin ^{[4
]}

Gedikbasi, Asuman ^{[22
]}

Goknar, Nilufer ^{[23
]}

Guven, Sercin ^{[5
]}

Hacihamdioglu, Duygu ^{[24
]}

Jankauskiene, Augustina ^{[25
]}

Kalyoncu, Mukaddes ^{[26
]}

Kavukcu, Salih ^{[9
]}

Kenan, Bahriye Uzun ^{[12
]}

Kucuk, Nuran ^{[27
]}

Kural, Bahar ^{[28
]}

Litwin, Mieczyslaw ^{[29
]}

Montini, Giovanni ^{[30
,31
]}

Morello, William ^{[30
]}

Obrycki, Lukasz ^{[29
]}

Omer, Beyhan ^{[32
]}

Oner, Huseyin Adil ^{[2
]}

Ozdemir, Ebru Misirli ^{[33
]}

Ozkayin, Nese ^{[34
]}

Paripovic, Dusan ^{[35
]}

Pehlivanoglu, Cemile ^{[36
]}

Saygili, Seha ^{[37
]}

Schaefer, Franz ^{[38
]}

Schaefer, Susanne ^{[38
]}

Sonmez, Ferah ^{[39
]}

Tabel, Yilmaz ^{[40
]}

Tas, Nesrin ^{[21
]}

Tasdemir, Mehmet ^{[10
,41
]}

Teixeira, Ana ^{[3
]}

Tekcan, Demet ^{[8
]}

Topaloglu, Rezan ^{[21
]}

机构：

[1] Istanbul Univ, Inst Child Hlth, Dept Pediat Basic Sci, Istanbul, Turkiye

[2] Istanbul Univ, Istanbul Fac Med, Div Pediat Nephrol, Istanbul, Turkiye

[3] Univ Porto, Ctr Hospitalar, Div Pediat Nephrol, Ctr Materno Infantil Norte, Porto, Portugal

[4] Celal Bayar Univ, Fac Med, Div Pediat Nephrol, Manisa, Turkiye

[5] Marmara Univ, Fac Med, Div Pediat Nephrol, Istanbul, Turkiye

[6] Erzurum Training & Res Hosp, Pediat Nephrol, Erzurum, Turkiye

[7] Cukurova Univ, Fac Med, Div Pediat Nephrol, Adana, Turkiye

[8] Ondokuz Mayis Univ, Fac Med, Div Pediat Nephrol, Samsun, Turkiye

[9] Dokuz Eylul Univ, Fac Med, Div Pediat Nephrol, Izmir, Turkiye

[10] Koc Univ, Div Pediat Nephrol, Sch Med, Dept Pediat, Istanbul, Turkiye

[11] Ege Univ, Fac Med, Div Pediat Nephrol, Izmir, Turkiye

[12] Gazi Univ, Fac Med, Div Pediat Nephrol, Ankara, Turkiye

[13] Akdeniz Univ, Fac Med, Div Pediat Nephrol, Antalya, Turkiye

[14] Univ Hlth Sci, Tepecik Training & Res Hosp, Div Pediat Nephrol, Izmir, Turkiye

[15] Izmir Katip Celebi Univ, Fac Med, Div Pediat Nephrol, Izmir, Turkiye

[16] Univ Hlth Sci, Dr Behcet Uz Children Dis Training & Res Hosp, Div Pediat Nephrol, Izmir, Turkiye

[17] Uludag Univ, Fac Med, Div Pediat Nephrol, Bursa, Turkiye

[18] Istanbul Univ, Istanbul Fac Med, Dept Med Microbiol, Istanbul, Turkiye

[19] Univ Hlth Sci, Okmeydani Training & Res Hosp, Div Pediat Nephrol, Istanbul, Turkiye

[20] Erciyes Univ, Fac Med, Div Pediat Nephrol, Kayseri, Turkiye

[21] Hacettepe Univ, Fac Med, Div Pediat Nephrol, Ankara, Turkiye

[22] Istanbul Univ, Inst Child Hlth, Dept Rare Dis, Istanbul, Turkiye

[23] Univ Hlth Sci, Bagcilar Training & Res Hosp, Div Pediat Nephrol, Istanbul, Turkiye

[24] Bahcesehir Univ, Fac Med, Div Pediat Nephrol, Istanbul, Turkiye

[25] Vilnius Univ, Inst Clin Med, Clin Pediat, Vilnius, Lithuania

[26] Karadeniz Tech Univ, Fac Med, Div Pediat Nephrol, Trabzon, Turkiye

[27] Kartal Training & Res Hosp, Div Pediat Nephrol, Istanbul, Turkiye

[28] Hlth Sci Univ Bakirkoy Sadi Konuk Training, Res Hosp, Dept Pediat, Istanbul, Turkiye

[29] Childrens Mem Hlth Inst, Div Nephrol, Kidney Transplantat & Hypertens, Warsaw, Poland

[30] Osped Maggiore Policlin, Fdn IRCCS CaGranda, Pediat Nephrol Dialysis & Transplant Unit, Milan, Italy

[31] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy

[32] Istanbul Univ, Istanbul Fac Med, Dept Biochem, Istanbul, Turkiye

[33] Okmeydani Training & Res Hosp, Dept Pediat, Istanbul, Turkiye

[34] Trakya Univ, Fac Med, Div Pediat Nephrol, Edirne, Turkiye

[35] Univ Childrens Hosp, Div Pediat Nephrol, Belgrade, Serbia

[36] Umraniye Training & Res Hosp, Div Pediat Nephrol, Istanbul, Turkiye

[37] Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Div Pediat Nephrol, Istanbul, Turkiye

[38] Heidelberg Univ, Ctr Pediat & Adolescent Med, Div Pediat Nephrol, Heidelberg, Germany

[39] Adnan Menderes Univ, Fac Med, Div Pediat Nephrol, Aydin, Turkiye

[40] Inonu Univ, Fac Med, Div Pediat Nephrol, Malatya, Turkiye

[41] Istinye Univ, Liv Hosp Ulus, Fac Med, Dept Pediat Nephrol, Istanbul, Turkiye

[42] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Div Pediat Nephrol, Istanbul, Turkiye

[43] Dortcelik Childrens Hosp, Div Pediat Nephrol, Bursa, Turkiye

[44] Bursa City Hosp, Div Pediat Nephrol, Bursa, Turkiye

[45] Istanbul Univ, Istanbul Fac Med, Div Pediat Emergency, Istanbul, Turkiye

[46] Univ Hlth Sci, Kanuni Sultan Suleyman Res & Training Hosp, Dept Pediat, Div Pediat Nephrol, Istanbul, Turkiye

[47] Univ Hlth Sci, Kanuni Sultan Suleyman Res & Training Hosp, Dept Pediat, Istanbul, Turkiye

[48] Pamukkale Univ, Fac Med, Div Pediat Nephrol, Denizli, Turkiye

[49] Istanbul Univ, Istanbul Fac Med, Dept Biostat, Istanbul, Turkiye

来源：

PEDIATRIC NEPHROLOGY | 2024年 / 39卷 / 02期

关键词：

Toll-like receptor 4; TLR4; Urinary tract infection; UTI; UTILISE study; INTERLEUKIN-8; EXPRESSION; UTI;

D O I：

10.1007/s00467-023-06063-0

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background One of the most common bacterial infections in childhood is urinary tract infection (UTI). Toll-like receptors (TLRs) contribute to immune response against UTI recognizing specific pathogenic agents. Our aim was to determine whether soluble TLR4 (sTLR4), soluble TLR5 (sTLR5) and interleukin 8 (IL-8) can be used as biomarkers to diagnose UTI. We also aimed to reveal the relationship between urine Heat Shock Protein 70 (uHSP70) and those biomarkers investigated in this study.Methods A total of 802 children from 37 centers participated in the study. The participants (n = 282) who did not meet the inclusion criteria were excluded from the study. The remaining 520 children, including 191 patients with UTI, 178 patients with non-UTI infections, 50 children with contaminated urine samples, 26 participants with asymptomatic bacteriuria and 75 healthy controls were included in the study. Urine and serum levels of sTLR4, sTLR5 and IL-8 were measured at presentation in all patients and after antibiotic treatment in patients with UTI.Results Urine sTLR4 was higher in the UTI group than in the other groups. UTI may be predicted using 1.28 ng/mL as cut-off for urine sTLR4 with 68% sensitivity and 65% specificity (AUC = 0.682). In the UTI group, urine sTLR4 levels were significantly higher in pyelonephritis than in cystitis (p < 0.0001). Post-treatment urine sTLR4 levels in the UTI group were significantly lower than pre-treatment values (p < 0.0001).Conclusions Urine sTLR4 may be used as a useful biomarker in predicting UTI and subsequent pyelonephritis in children with UTI.

引用

页码：483 / 491

页数：9

共 39 条

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Shen, Qian
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PEDIATRIC NEPHROLOGY, 2021, 36 (09) : 2933 - 2933
[32] Heat shock protein 72 (HSPA1B) gene polymorphism and toll-like receptor (TLR) 4 mutation are associated with increased risk of urinary tract infection in children
Karoly, E.
Banki, N. F.
Szebeni, B.
Szabo, A. J.
Tulassay, T.
Reusz, G. S.
Fekete, A.
PEDIATRIC NEPHROLOGY, 2007, 22 (09) : 1474 - 1474
[33] Heat Shock Protein 72 (HSPA1B) Gene Polymorphism and Toll-Like Receptor (TLR) 4 Mutation Are Associated with Increased Risk of Urinary Tract Infection in Children
Eva Karoly
Andrea Fekete
Nora F Banki
Beata Szebeni
Adam Vannay
Attila J Szabo
Tivadar Tulassay
Georg S Reusz
Pediatric Research, 2007, 61 : 371 - 374
[34] Heat shock protein 72 (HSPA1B) gene polymorphism and toll-like receptor (TLR) 4 mutation are associated with increased risk of urinary tract infection in children
Karoly, Eva
Fekete, Andrea
Banki, Nora F.
Szebeni, Beata
Vannay, Adam
Szabo, Attila J.
Tulassay, Tivadar
Reusz, Georg S.
PEDIATRIC RESEARCH, 2007, 61 (03) : 371 - 374
[35] Development of risk prediction models to predict urine culture growth for adults with suspected urinary tract infection in the emergency department: protocol for an electronic health record study from a single UK university hospital
Patrick Rockenschaub
Martin J. Gill
David McNulty
Orlagh Carroll
Nick Freemantle
Laura Shallcross
Diagnostic and Prognostic Research, 4 (1)
[36] Heat shock protein 722 (HSPAIB) gene polymorphism and toll-like receptor (TLR) 4 mutation are associated with increased risk of urinary tract infection in children (vol 61, pg 371)
Szabo, Attila J.
Reusz, Georg S.
PEDIATRIC RESEARCH, 2007, 62 (04) : 482 - 482
[37] TLR4/Asp299Gly, CD14/C-260T, plasma levels of the soluble receptor CD14 and the risk of coronary heart disease: The PRIME Study
P E Morange
L Tiret
N Saut
G Luc
D Arveiler
J Ferrieres
P Amouyel
A Evans
P Ducimetiere
F Cambien
I Juhan-Vague
European Journal of Human Genetics, 2004, 12 : 1041 - 1049
[38] TLR4/Asp299Gly, CD14/C-260T, plasma levels of the soluble receptor CD14 and the risk of coronary heart disease: The PRIME Study
Morange, PE
Tiret, L
Saut, N
Luc, G
Arveiler, D
Ferrieres, J
Amouyel, P
Evans, A
Ducimetiere, P
Cambien, F
Juhan-Vague, I
EUROPEAN JOURNAL OF HUMAN GENETICS, 2004, 12 (12) : 1041 - 1049
[39] Strikingly higher interleukin (IL)-1α, IL-1β and soluble interleukin-1 receptor antagonist (sIL-1RA) but similar IL-2, sIL-2R, IL-3, IL-4, IL-6, sIL-6R, IL-10, tumour necrosis factor (TNF)-α, transforming growth factor (TGF)-β2 and interferon IFN-γ urine levels in healthy females compared to healthy males:: protection against urinary tract injury?
Sadeghi, M
Daniel, V
Naujokat, C
Weimer, R
Opelz, G
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2005, 142 (02): : 312 - 317

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