Visible-Light-Photoexcited Palladium-Catalyzed Silylmethylation of Benzyl Alcohol Derivatives

被引：1
|
作者：
Mizoguchi, Haruki [1 ]
Yoshida, Ryuji [1 ]
Ikeda, Haruka [1 ]
Sakakura, Akira [1 ]
机构：
[1] Okayama Univ, Grad Sch Nat Sci & Technol, 3-1-1 Tsushima Naka,Kita Ku, Okayama 7008530, Japan
来源：
SYNLETT | 2023年 / 34卷 / 20期
关键词：
palladium catalysis; photochemical reaction; silylmethylation; arylation; siloxacycle; C-C bond formation; C-H BONDS; HECK REACTION; ALKYL-HALIDES;
D O I：
10.1055/s-0042-1752736
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An intramolecular C-H silylmethylation of benzylic alcohol derivatives catalyzed by a visible-light-photoexcited palladium complex was developed. Irradiation of the palladium complex with blue LEDs resulted in efficient activation of a C-I bond, and subsequent intramolecular radical arylation afforded siloxacycle products. Selective protonation or oxidation of the C-Si bond of the cyclized materials afforded ortho-methylated and ortho-hydroxymethylated derivatives of the benzylic alcohol derivatives.
引用
收藏
页码：2451 / 2454
页数：4
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