Visible-Light-Photoexcited Palladium-Catalyzed Silylmethylation of Benzyl Alcohol Derivatives

被引：1

作者：

Mizoguchi, Haruki ^{[1
]}

Yoshida, Ryuji ^{[1
]}

Ikeda, Haruka ^{[1
]}

Sakakura, Akira ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Nat Sci & Technol, 3-1-1 Tsushima Naka,Kita Ku, Okayama 7008530, Japan

来源：

SYNLETT | 2023年 / 34卷 / 20期

关键词：

palladium catalysis; photochemical reaction; silylmethylation; arylation; siloxacycle; C-C bond formation; C-H BONDS; HECK REACTION; ALKYL-HALIDES;

D O I：

10.1055/s-0042-1752736

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An intramolecular C-H silylmethylation of benzylic alcohol derivatives catalyzed by a visible-light-photoexcited palladium complex was developed. Irradiation of the palladium complex with blue LEDs resulted in efficient activation of a C-I bond, and subsequent intramolecular radical arylation afforded siloxacycle products. Selective protonation or oxidation of the C-Si bond of the cyclized materials afforded ortho-methylated and ortho-hydroxymethylated derivatives of the benzylic alcohol derivatives.

引用

页码：2451 / 2454

页数：4

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