Triply Selective & Sequential Diversification at Csp3: Expansion of Alkyl Germane Reactivity for C-C & C-Heteroatom Bond Formation

被引：7

作者：

Ahrweiler, Eric ^{[1
]}

Schoetz, Markus D. ^{[1
]}

Singh, Gurdeep ^{[1
]}

Bindschaedler, Quentin P. ^{[1
]}

Sorroche, Alba ^{[1
]}

Schoenebeck, Franziska ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2024年 / 63卷 / 16期

基金：

欧盟地平线“2020”; 欧洲研究理事会;

关键词：

site-selectivity; alkyl germane; modularity; catalysis; radical chemistry; photochemistry; TERTIARY BORONIC ESTERS; REDOX-ACTIVE ESTERS; CONSTRUCTION; SECONDARY; ACCESS; FUNCTIONALIZATION; HALIDES; OXYGEN;

D O I：

10.1002/anie.202401545

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the triply selective and sequential diversification of a single C-sp(3) carbon carrying Cl, Bpin and GeEt3 for the modular and programmable construction of sp(3)-rich molecules. Various functionalizations of C-sp(3)-Cl and C-sp(3)-BPin (e.g. alkylation, arylation, homologation, amination, hydroxylation) were tolerated by the C-sp(3)-GeEt3 group. Moreover, the methodological repertoire of alkyl germane functionalization was significantly expanded beyond the hitherto known Giese addition and arylation to alkynylation, alkenylation, cyanation, halogenation, azidation, C-S bond formation as well as the first demonstration of stereo-selective functionalization of a C-sp(3)-[Ge] bond.

引用

页数：6

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