Nickel-catalyzed mild synthesis of functional γ-amino butyric acid esters via direct α-C(sp3)-H allylation of N-alkyl anilines with allyl sulfones

Herein, by employing a readily available Ni(OAc)(2)center dot 4H(2)O/TBHP catalyst system, we present a new method for mild synthesis of alpha-methylene-gamma-amino butyric acid esters via direct alpha-C(sp(3))-H allylation of N-alkyl anilines with allyl sulfones under oxidative nickel catalysis. The synthetic protocol proceeds with good substrate and functional group compatibility, operational simplicity, the use of base metal catalysts and easily accessible feedstocks, and no need for pre-functionalization of the alpha-site of N-alkyl anilines. In addition, the obtained products are applicable for further elaboration of functional molecules.