Recent advances in gout drugs

被引：36

作者：

Shi, Cheng ^{[1
]}

Zhou, Ziting ^{[1
]}

Chi, Xiaowei ^{[1
]}

Xiu, Siyu ^{[1
]}

Yi, Chuxiao ^{[1
]}

Jiang, Ziqiong ^{[1
]}

Chen, Ruyi ^{[1
]}

Zhang, Liangren ^{[1
]}

Liu, Zhenming ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2023年 / 245卷

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

Gout; Inflammatory arthritis; Drug discovery; Uric acid; NLRP3; INFLAMMASOME; URIC-ACID; XANTHINE-OXIDASE; PHASE; 2A; ASYMPTOMATIC HYPERURICEMIA; REFRACTORY GOUT; DOUBLE-BLIND; URATE; INHIBITOR; MANAGEMENT;

D O I：

10.1016/j.ejmech.2022.114890

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Gout is an autoinflammatory disease caused by the deposition of urate crystals. As the most common inflam-matory arthritis, gout has a high incidence and can induce various severe complications. At present, there is no effective cure method in the world. With the deepening of medical research, gout treatment drugs continue to progress. In this review, we provide a landscape view of the current state of the research on gout treatment drugs, including the research progress of anti-inflammatory and analgesic drugs, drugs that promote uric acid excretion, and drugs that inhibit uric acid production. We mainly emphasize the understanding of gout as an auto -inflammatory disease and the discovery strategy of related gout drugs to provide a systematic and theoretical basis for the new exploration of gout drug discovery.

引用

页数：15

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