Virologic Nonsuppression and HIV Drug Resistance Among People Who Inject Drugs and Their Sexual and Injecting Partners in Kenya

被引：0

作者：

Chohan, Bhavna H. ^{[1
,2
]}

Kingston, Hanley ^{[3
]}

Tseng, Ashley S. ^{[4
]}

Sambai, Betsy ^{[5
]}

Guthrie, Brandon L. ^{[1
,4
]}

Wilkinson, Eduan ^{[6
,7
]}

Giandhari, Jennifer ^{[6
]}

Mbogo, Loice W. ^{[5
]}

Monroe-Wise, Aliza ^{[1
]}

Masyuko, Sarah ^{[1
]}

Bosire, Rose ^{[2
]}

Ludwig-Barron, Natasha T. ^{[1
,4
]}

Sinkele, William ^{[8
]}

Bukusi, David ^{[9
]}

de Oliveria, Tulio ^{[1
,6
,7
]}

Farquhar, Carey ^{[1
,4
,10
]}

Herbeck, Joshua T. ^{[1
]}

机构：

[1] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[2] Kenya Govt Med Res Ctr, Nairobi, Kenya

[3] Univ Washington, Inst Publ Hlth Genet, Seattle, WA USA

[4] Univ Washington, Dept Epidemiol, Seattle, WA USA

[5] Univ Washington, Global Assistance Program Kenya, Nairobi, Kenya

[6] Univ KwaZulu Natal, Nelson R Mandela Sch Med, KwaZulu Natal Res Innovat & Sequencing Platform, Durban, South Africa

[7] Stellenbosch Univ, Ctr Epidem Response & Innovat CERI, Sch Data Sci & Computat Thinking, Stellenbosch, South Africa

[8] SAPTA, Support Addict Prevent & Treatment Afr, Nairobi, Kenya

[9] Kenyatta Natl Hosp, Nairobi, Kenya

[10] Univ Washington, Dept Med, Seattle, WA 98195 USA

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2024年 / 40卷 / 05期

关键词：

HIV; PWID; virologic nonsuppression; HIV drug resistance; Kenya;

D O I：

10.1089/aid.2023.0068

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated the prevalence and correlates of HIV viral nonsuppression and HIV drug resistance (HIV-DR) in a cohort of people who inject drugs living with HIV (PWID-LH) and their sexual and injecting partners living with HIV in Kenya. HIV-DR testing was performed on participants with viral nonsuppression. Of 859 PWID-LH and their partners, 623 (72.5%) were on antiretroviral therapy (ART) >= 4 months and 148/623 (23.8%) were not virally suppressed. Viral nonsuppression was more common among younger participants and those on ART for a shorter duration. Among 122/148 (82.4%) successfully sequenced samples, 55 (45.1%) had detectable major HIV-DR mutations, mainly to non-nucleoside and nucleotide reverse transcriptase inhibitors (NNRTI and NRTI). High levels of HIV-DR among those with viral nonsuppression suggests need for viral load monitoring, adherence counseling, and timely switching to alternate ART regimens in this key population.

引用

页码：240 / 250

页数：11

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