Non-coding RNAs in renal cell carcinoma: Implications for drug resistance

被引：6

作者：

Liu, Yiqi ^{[1
]}

Zhang, Hu ^{[2
]}

Fang, Yuan ^{[3
]}

Tang, Dongshan ^{[4
]}

Luo, Zhigang ^{[5
]}

机构：

[1] Univ South China, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China

[2] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Urol, Hengyang 421001, Hunan, Peoples R China

[3] Kunming Med Univ, Affiliated Hosp 1, Organ Transplantat Ctr, Kunming 650032, Yunnan, Peoples R China

[4] Univ South China, Sch Resources & Environm & Safety Engn, Hengyang 421001, Hunan, Peoples R China

[5] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 164卷

关键词：

Renal cell carcinoma; Drug resistance; Non -coding RNAs; Biomarkers; MiRNAs; SUNITINIB RESISTANCE; TUMOR PROGRESSION; CIRCULAR RNAS; BREAST-CANCER; TUMORIGENESIS; CHEMORESISTANCE; TRANSCRIPTION; ANGIOGENESIS; METASTASIS; INHIBITION;

D O I：

10.1016/j.biopha.2023.115001

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Renal cell carcinoma (RCC) represents a malignant tumor of the urinary system. Individuals with early-stage RCC could be cured by surgical treatment, but a considerable number of cases of advanced RCC progress to drug resistance. Recently, numerous reports have demonstrated that a variety of non-coding RNAs (ncRNAs) contribute to tumor occurrence and development. ncRNAs can act as oncogenic or tumor suppressor genes to regulate proliferation, migration, drug resistance and other processes in RCC cells through a variety of signaling pathways. Considering the lack of treatment options for advanced RCC after drug resistance, ncRNAs may be a good choice as biomarkers of drug resistance in RCC and targets to overcome drug resistance. In this review, we discussed the effects of ncRNAs on drug resistance in RCC and the great potential of ncRNAs as a biomarker of or a new therapeutic method in RCC.

引用

页数：10

共 50 条

[21] Genetic and epigenetic regulation of non-coding RNAs: Implications in cancer metastasis, stemness and drug resistance
Dakal, Tikam Chand
Philip, Reya Rene
Bhushan, Ravi
Sonar, Priyanka Vijay
Rajagopal, Senthilkumar
Kumar, Abhishek
PATHOLOGY RESEARCH AND PRACTICE, 2025, 266
[22] Non-coding RNAs as drug targets
Masayuki Matsui
David R. Corey
Nature Reviews Drug Discovery, 2017, 16 : 167 - 179
[23] Non-coding RNAs as drug targets
Matsui, Masayuki
Corey, David R.
NATURE REVIEWS DRUG DISCOVERY, 2017, 16 (03) : 167 - 179
[24] Non-Coding RNAs in Hepatocellular Carcinoma
Korsch, Mascha
Margetts, Alexander
Wahlestedt, Claes
Lohse, Ines
LIVERS, 2022, 2 (03): : 185 - 213
[25] Non-coding RNA in drug resistance of hepatocellular carcinoma
Ding, Bisha
Lou, Weiyang
Xu, Liang
Fan, Weimin
BIOSCIENCE REPORTS, 2018, 38
[26] Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications
Chun-Ming Wong
Felice Ho-Ching Tsang
Irene Oi-Lin Ng
Nature Reviews Gastroenterology & Hepatology, 2018, 15 : 137 - 151
[27] Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications
Wong, Chun-Ming
Tsang, Felice Ho-Ching
Ng, Irene Oi-Lin
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2018, 15 (03) : 137 - 151
[28] ncDR: a comprehensive resource of non-coding RNAs involved in drug resistance
Dai, Enyu
Yang, Feng
Wang, Jing
Zhou, Xu
Song, Qian
An, Weiwei
Wang, Lihong
Jiang, Wei
BIOINFORMATICS, 2017, 33 (24) : 4010 - 4011
[29] The role of exosomal long non-coding RNAs in cancer drug resistance
De los Santos, Mireia Cruz
Dragomir, Mihnea P.
Calin, George A.
CANCER DRUG RESISTANCE, 2019, 2 (04) : 1178 - 1192
[30] The Emerging Role of Non-coding RNAs in Drug Resistance of Ovarian Cancer
Lan, Hua
Yuan, Jing
Zeng, Da
Liu, Chu
Guo, Xiaohui
Yong, Jiahui
Zeng, Xiangyang
Xiao, Songshu
FRONTIERS IN GENETICS, 2021, 12

← 1 2 3 4 5 →