Neuroprotective Roles of Apelin-13 in Neurological Diseases

被引：17

作者：

Zhang, Yang ^{[1
]}

Jiang, Weiwei ^{[4
]}

Sun, Wenjie ^{[1
]}

Guo, Weiming ^{[3
]}

Xia, Beibei ^{[4
]}

Shen, Xiangru ^{[4
]}

Fu, Mingyuan ^{[4
]}

Wan, Teng ^{[2
,4
]}

Yuan, Mei ^{[1
]}

机构：

[1] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Neurol, Hengyang, Hunan, Peoples R China

[2] Shenzhen Univ, Huazhong Univ Sci & Technol, Union Shenzhen Hosp, Dept Neurol,Affiliated Hosp 6,Hlth Sci Ctr, Shenzhen 518060, Peoples R China

[3] Shenzhen Univ, Huazhong Univ Sci & Technol, Union Shenzhen Hosp, Dept Sports Med,Affiliated Hosp 6,Hlth Sci Ctr, Shenzhen 518060, Peoples R China

[4] Univ South China, Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China

来源：

NEUROCHEMICAL RESEARCH | 2023年 / 48卷 / 06期

关键词：

Apelin-13; Neurological diseases; Neuroinflammation; Apoptosis; Neuroprotection; SPINAL-CORD-INJURY; BLOOD-BRAIN-BARRIER; ISCHEMIA-REPERFUSION INJURY; GLOBAL BURDEN; HPA AXIS; PROTECTS; RECEPTOR; STROKE; APOPTOSIS; LIGAND;

D O I：

10.1007/s11064-023-03869-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apelin is a natural ligand for the G protein-coupled receptor APJ, and the apelin/APJ system is widely distributed in vivo. Among the apelin family, apelin-13 is the major apelin isoform in the central nervous system and cardiovascular system, and is involved in the regulation of various physiopathological mechanisms such as apoptosis, neuroinflammation, angiogenesis, and oxidative stress. Apelin is currently being extensively studied in the nervous system, and apelin-13 has been shown to be associated with the onset and progression of a variety of neurological disorders, including stroke, neurodegenerative diseases, epilepsy, spinal cord injury (SCI), and psychiatric diseases. This study summarizes the pathophysiological roles of apelin-13 in the development and progression of neurological related diseases.

引用

页码：1648 / 1662

页数：15

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