Photodynamic therapy for infected foot ulcers in people with diabetes mellitus: a systematic review

被引:3
|
作者
Brandao, Maria Girlane Sousa Albuquerque [1 ,7 ]
Ximenes, Maria Aline Moreira [2 ]
de Sousa, Danilo Ferreira [1 ,2 ]
Veras, Vivian Saraiva [3 ]
Barros, Livia Moreira [3 ]
Rabeh, Soraia Assad Nasbine [4 ]
Costa, Idevania Geraldina [5 ]
de Araujo, Thiago Moura [6 ]
机构
[1] Univ Sao Paulo, Nursing Sch, Ribeirao Preto, SP, Brazil
[2] Univ Fed Ceara UFC, Dept Nursing, Fortaleza, CE, Brazil
[3] Univ Integracao Int Lusofonia Afro Brasileira, Dept Nursing, Redencao, CE, Brazil
[4] Univ Sao Paulo, Dept Nursing, Ribeirao Preto, SP, Brazil
[5] Lakehead Univ, Dept Nursing, Thunder Bay, ON, Canada
[6] Univ Integracao Int Lusofonia Afro Brasileira, Hlth Sci Inst, Dept Nursing, Redencao, CE, Brazil
[7] Ave Governador Lucas Nogueira Garces,570 Cidade Un, BR-14051510 Ribeirao Preto, SP, Brazil
来源
SAO PAULO MEDICAL JOURNAL | 2023年 / 141卷 / 06期
关键词
Photochemotherapy; Oxidative stress; Infections; Diabetic foot; Laser therapy; PDT;
D O I
10.1590/1516-3180.2022.0476.27022023
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND: Ulceration of the feet in patients with diabetes is a frequent complication that increases morbidity, mortality, hospitalization, treatment costs, and non-traumatic amputations. OBJECTIVE: To present a systematic review of the treatment of patients with diabetes mellitus and infect-ed foot ulcers using photodynamic therapy.DESIGN AND SETTING: A systematic review was performed in the postgraduate program in nursing at the Universidade da Integracao Internacional da Lusofonia Afro-Brasileira, Ceara, Brazil. METHODS: PubMed, CINAHL, Web of Science, EMBASE, Cochrane Library, Scopus, and LILACS databases were screened. The methodological quality, risk of bias, and quality of evidence of each study were as-sessed. Review Manager was used for the meta-analysis.RESULTS: Four studies were included. They highlighted significantly better outcomes in patient groups treated with photodynamic therapy than those in the control groups that were treated with topical col-lagenase and chloramphenicol (P = 0.036), absorbent (P < 0.001), or dry covers (P = 0.002). Significant improvements were noted in terms of the microbial load in the ulcers and tissue repair, with a reported reduction in the need for amputation by up to 35 times. Photodynamic therapy resulted in significantly better outcomes between the experimental and control groups (P = 0.04). CONCLUSION: Photodynamic therapy is significantly more effective in treating infected foot ulcers than standard therapies. SYSTEMATIC REVIEW REGISTRATION: International Prospective Register of Systematic Reviews (PROS-PERO) -CRD42020214187, https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=214187.
引用
收藏
页数:9
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