MicroRNAs as prospective biomarkers, therapeutic targets and pharmaceuticals in neuroblastoma

被引：3
|
作者：
Andreeva, Natalia [1 ]
Usman, Natalia [1 ]
Druy, Alexander [1 ]
机构：
[1] Dmitry Rogachev Natl Med Res Ctr Pediat Hematol On, 1 Samory Mashela Str, Moscow 117997, Russia
来源：
MOLECULAR BIOLOGY REPORTS | 2023年 / 50卷 / 02期
关键词：
MicroRNA; Neuroblastoma; MYCN; Differentiation; Cell-free nucleic acids; MYCN-AMPLIFIED NEUROBLASTOMA; INHIBITS TUMOR-GROWTH; DOWN-REGULATION; RETINOIC ACID; CELL-PROLIFERATION; SIGNALING NETWORK; LIN28/LET-7; AXIS; PROMOTES; DIFFERENTIATION; SUPPRESSOR;
D O I：
10.1007/s11033-022-08137-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neuroblastomas, the most prevalent malignant solid neoplasms of childhood, originate from progenitor cells of the sympathetic nervous system. Their genetic causation is diverse and involves multiple molecular mechanisms. This review highlights multiple roles of microRNA in neuroblastoma pathogenesis and discusses the prospects of harnessing these important natural regulator molecules as biomarkers, therapeutic targets and pharmaceuticals in neuroblastoma.
引用
收藏
页码：1895 / 1912
页数：18
相关论文
共 50 条
  • [31] Exosomal microRNAs as potential biomarkers and therapeutic targets in corneal diseases
    Arora, Swati
    Verma, Nagendra
    MOLECULAR VISION, 2024, 30 : 92 - 106
  • [32] MicroRNAs Determining Inflammation as Novel Biomarkers and Potential Therapeutic Targets
    Kotsinas, Athanassios
    Sigala, Fragkiska
    Garbis, Spiros D.
    Galyfos, Giorgos
    Filis, Konstantinos
    Vougas, Konstantinos
    Papalampros, Alexandros
    Johnson, Elizabeth E.
    Chronopoulos, Efstathios
    Georgakilas, Alexandros G.
    Gorgoulis, Vassilis G.
    CURRENT MEDICINAL CHEMISTRY, 2015, 22 (22) : 2666 - 2679
  • [33] MicroRNAs: new biomarkers and therapeutic targets after cardiac arrest?
    Devaux, Yvan
    Stammet, Pascal
    Friberg, Hans
    Hassager, Christian
    Kuiper, Michael A.
    Wise, Matt P.
    Nielsen, Niklas
    CRITICAL CARE, 2015, 19
  • [34] MicroRNAs as Regulators, Biomarkers, and Therapeutic Targets in Autism Spectrum Disorder
    Yao, Tong-Tong
    Chen, Lei
    Du, Yang
    Jiang, Zhong-Yong
    Cheng, Yong
    MOLECULAR NEUROBIOLOGY, 2025, 62 (04) : 5039 - 5056
  • [35] Emerging Roles of microRNAs as Biomarkers and Therapeutic Targets for Diabetic Neuropathy
    Fan, Baoyan
    Chopp, Michael
    Zhang, Zheng Gang
    Liu, Xian Shuang
    FRONTIERS IN NEUROLOGY, 2020, 11
  • [36] MicroRNAs in mesothelioma: from tumour suppressors and biomarkers to therapeutic targets
    Reid, Glen
    JOURNAL OF THORACIC DISEASE, 2015, 7 (06) : 1031 - 1040
  • [37] MicroRNAs as unique biomarkers and potential therapeutic targets for diabetic retinopathy
    Smit-McBride, Zeljka
    Wu, YanYing
    Prajogo, Stefan
    Mehmi, Sonia
    Meleppat, Ratheesh Kumar
    Oltjen, Sharon L.
    Zawadzki, Robert
    Morse, Lawrence S.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2020, 61 (07)
  • [38] MicroRNAs as novel predictive biomarkers and therapeutic targets in colorectal cancer
    Stiegelbauer, Verena
    Perakis, Samantha
    Deutsch, Alexander
    Ling, Hui
    Gerger, Armin
    Pichler, Martin
    WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (33) : 11727 - 11735
  • [39] Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets
    Wang, Feng
    Chen, Chen
    Wang, Daowen
    FRONTIERS OF MEDICINE, 2014, 8 (04) : 404 - 418
  • [40] Dysregulation of microRNAs in autoimmune diseases: Pathogenesis, biomarkers and potential therapeutic targets
    Long, Hai
    Wang, Xin
    Chen, Yongjian
    Wang, Ling
    Zhao, Ming
    Lu, Qianjin
    CANCER LETTERS, 2018, 428 : 90 - 103
12345