MicroRNAs as prospective biomarkers, therapeutic targets and pharmaceuticals in neuroblastoma

被引：3
|
作者：
Andreeva, Natalia [1 ]
Usman, Natalia [1 ]
Druy, Alexander [1 ]
机构：
[1] Dmitry Rogachev Natl Med Res Ctr Pediat Hematol On, 1 Samory Mashela Str, Moscow 117997, Russia
来源：
MOLECULAR BIOLOGY REPORTS | 2023年 / 50卷 / 02期
关键词：
MicroRNA; Neuroblastoma; MYCN; Differentiation; Cell-free nucleic acids; MYCN-AMPLIFIED NEUROBLASTOMA; INHIBITS TUMOR-GROWTH; DOWN-REGULATION; RETINOIC ACID; CELL-PROLIFERATION; SIGNALING NETWORK; LIN28/LET-7; AXIS; PROMOTES; DIFFERENTIATION; SUPPRESSOR;
D O I：
10.1007/s11033-022-08137-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neuroblastomas, the most prevalent malignant solid neoplasms of childhood, originate from progenitor cells of the sympathetic nervous system. Their genetic causation is diverse and involves multiple molecular mechanisms. This review highlights multiple roles of microRNA in neuroblastoma pathogenesis and discusses the prospects of harnessing these important natural regulator molecules as biomarkers, therapeutic targets and pharmaceuticals in neuroblastoma.
引用
收藏
页码：1895 / 1912
页数：18
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